Names & Taxonomy
- Uniprot ID:
- P51512
- Entry Name:
- MMP16_HUMAN
- Status:
- reviewed
- Protein Names:
- Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP)
- Gene Names:
- MMP16 MMPX2
- Gene Names Primary:
- MMP16
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 607
- Sequence:
- MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform Long: Cell membrane
Function
- Function:
- Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding affinity than TIMP-2 for the short isoform.
- Active Site:
- ACT_SITE 247 247
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- cell surface
Golgi lumen
integral component of plasma membrane
plasma membrane
proteinaceous extracellular matrix
calcium ion binding
enzyme activator activity
metalloendopeptidase activity
zinc ion binding
chondrocyte proliferation
collagen catabolic process
craniofacial suture morphogenesis
embryonic cranial skeleton morphogenesis
endochondral ossification
extracellular matrix disassembly
extracellular matrix organization
positive regulation of catalytic activity - Gene Ontology Biological Process:
- chondrocyte proliferation
collagen catabolic process
craniofacial suture morphogenesis
embryonic cranial skeleton morphogenesis
endochondral ossification
extracellular matrix disassembly
extracellular matrix organization
positive regulation of catalytic activity - Gene Ontology Molecular Function:
- calcium ion binding
enzyme activator activity
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- cell surface
Golgi lumen
integral component of plasma membrane
plasma membrane
proteinaceous extracellular matrix - Keywords:
- 3D-structure
Alternative splicing
Calcium
Cell membrane
Cleavage on pair of basic residues
Collagen degradation
Complete proteome
Disulfide bond
Extracellular matrix
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Protease
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix
Zinc
Zymogen