Names & Taxonomy
- Uniprot ID:
- P50993
- Entry Name:
- AT1A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2)
- Gene Names:
- ATP1A2 KIAA0778
- Gene Names Primary:
- ATP1A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1020
- Sequence:
- MGRGAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKGLTNQRAQDVLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAAMEDEPSNDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINAEEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPEFTHENPLETRNICFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRTPIAMEIEHFIQLITGVAVFLGVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKRSPTWTALSRIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPFNSTNKYQLSIHEREDSPQSHVLVMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQNAYMELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPMSQVNPREAKACVVHGSDLKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLEDSYGQEWTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETALAAFLSYCPGMGVALRMYPLKVTWWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKETYY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
- Catalytic Activity:
- ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In).
- Active Site:
- ACT_SITE 374 374 4-aspartylphosphate intermediate.
- Gene Ontology Go:
- caveola
cytoplasm
cytosol
dendritic spine
endosome
extracellular vesicle
intercalated disc
intracellular membrane-bounded organelle
membrane
myelin sheath
plasma membrane
sodium:potassium-exchanging ATPase complex
T-tubule
ATP binding
chaperone binding
metal ion binding
sodium:potassium-exchanging ATPase activity
steroid hormone binding
adult locomotory behavior
ATP hydrolysis coupled proton transport
ATP metabolic process
cardiac conduction
cardiac muscle contraction
cell communication by electrical coupling involved in cardiac conduction
cellular potassium ion homeostasis
cellular response to mechanical stimulus
cellular response to steroid hormone stimulus
cellular sodium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
ion transmembrane transport
locomotion
membrane depolarization during cardiac muscle cell action potential
membrane repolarization
negative regulation of calcium ion transmembrane transport
negative regulation of calcium:sodium antiporter activity
negative regulation of cytosolic calcium ion concentration
negative regulation of heart contraction
negative regulation of striated muscle contraction
neurotransmitter uptake
potassium ion import
potassium ion import across plasma membrane
potassium ion transport
regulation of blood pressure
regulation of cardiac conduction
regulation of cardiac muscle cell contraction
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of glutamate uptake involved in transmission of nerve impulse
regulation of respiratory gaseous exchange by neurological system process
regulation of smooth muscle contraction
regulation of striated muscle contraction
regulation of synaptic transmission, glutamatergic
regulation of the force of heart contraction
regulation of vasoconstriction
relaxation of cardiac muscle
response to glycoside
response to nicotine
sodium ion export from cell
sodium ion transport
transmembrane transport
visual learning - Gene Ontology Biological Process:
- adult locomotory behavior
ATP hydrolysis coupled proton transport
ATP metabolic process
cardiac conduction
cardiac muscle contraction
cell communication by electrical coupling involved in cardiac conduction
cellular potassium ion homeostasis
cellular response to mechanical stimulus
cellular response to steroid hormone stimulus
cellular sodium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
ion transmembrane transport
locomotion
membrane depolarization during cardiac muscle cell action potential
membrane repolarization
negative regulation of calcium:sodium antiporter activity
negative regulation of calcium ion transmembrane transport
negative regulation of cytosolic calcium ion concentration
negative regulation of heart contraction
negative regulation of striated muscle contraction
neurotransmitter uptake
potassium ion import
potassium ion import across plasma membrane
potassium ion transport
regulation of blood pressure
regulation of cardiac conduction
regulation of cardiac muscle cell contraction
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of glutamate uptake involved in transmission of nerve impulse
regulation of respiratory gaseous exchange by neurological system process
regulation of smooth muscle contraction
regulation of striated muscle contraction
regulation of synaptic transmission, glutamatergic
regulation of the force of heart contraction
regulation of vasoconstriction
relaxation of cardiac muscle
response to glycoside
response to nicotine
sodium ion export from cell
sodium ion transport
transmembrane transport
visual learning - Gene Ontology Molecular Function:
- ATP binding
chaperone binding
metal ion binding
sodium:potassium-exchanging ATPase activity
steroid hormone binding - Gene Ontology Cellular Component:
- caveola
cytoplasm
cytosol
dendritic spine
endosome
extracellular vesicle
intercalated disc
intracellular membrane-bounded organelle
membrane
myelin sheath
plasma membrane
sodium:potassium-exchanging ATPase complex
T-tubule - Keywords:
- ATP-binding
Cell membrane
Complete proteome
Disease mutation
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Potassium
Potassium transport
Reference proteome
Sodium
Sodium transport
Sodium/potassium transport
Transmembrane
Transmembrane helix
Transport