Names & Taxonomy
- Uniprot ID:
- P50897
- Entry Name:
- PPT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1)
- Gene Names:
- PPT1 PPT
- Gene Names Primary:
- PPT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 306
- Sequence:
- MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGDSCCNPLSMGAIKKMVEKKIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQGYNAMGFSQGGQFLRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERLVQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVDSEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAHIIPFLG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome.
Function
- Function:
- Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
- Catalytic Activity:
- Palmitoyl- + H(2)O = palmitate + .
- Active Site:
- ACT_SITE 115 115
- Gene Ontology Go:
- axon
cytosol
dendrite
extracellular exosome
extracellular region
extracellular space
Golgi apparatus
lysosomal lumen
lysosome
membrane
membrane raft
neuronal cell body
nucleus
synaptic vesicle
palmitoyl-(protein) hydrolase activity
palmitoyl-CoA hydrolase activity
adult locomotory behavior
associative learning
brain development
cellular lipid metabolic process
cellular protein catabolic process
cofactor metabolic process
cofactor transport
grooming behavior
lipid catabolic process
long-chain fatty-acyl-CoA biosynthetic process
lysosomal lumen acidification
membrane raft organization
negative regulation of apoptotic process
negative regulation of cell growth
negative regulation of neuron apoptotic process
nervous system development
neuron development
neurotransmitter secretion
pinocytosis
positive regulation of pinocytosis
positive regulation of receptor-mediated endocytosis
protein catabolic process
protein depalmitoylation
protein transport
receptor-mediated endocytosis
regulation of phospholipase A2 activity
regulation of synapse structure or activity
response to stimulus
small molecule metabolic process
sphingolipid catabolic process
triglyceride biosynthetic process
visual perception - Gene Ontology Biological Process:
- adult locomotory behavior
associative learning
brain development
cellular lipid metabolic process
cellular protein catabolic process
cofactor metabolic process
cofactor transport
grooming behavior
lipid catabolic process
long-chain fatty-acyl-CoA biosynthetic process
lysosomal lumen acidification
membrane raft organization
negative regulation of apoptotic process
negative regulation of cell growth
negative regulation of neuron apoptotic process
nervous system development
neuron development
neurotransmitter secretion
pinocytosis
positive regulation of pinocytosis
positive regulation of receptor-mediated endocytosis
protein catabolic process
protein depalmitoylation
protein transport
receptor-mediated endocytosis
regulation of phospholipase A2 activity
regulation of synapse structure or activity
response to stimulus
small molecule metabolic process
sphingolipid catabolic process
triglyceride biosynthetic process
visual perception - Gene Ontology Molecular Function:
- palmitoyl-(protein) hydrolase activity
palmitoyl-CoA hydrolase activity - Gene Ontology Cellular Component:
- axon
cytosol
dendrite
extracellular exosome
extracellular region
extracellular space
Golgi apparatus
lysosomal lumen
lysosome
membrane
membrane raft
neuronal cell body
nucleus
synaptic vesicle - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Neurodegeneration
Neuronal ceroid lipofuscinosis
Polymorphism
Reference proteome
Sensory transduction
Signal
Vision