Names & Taxonomy
- Uniprot ID:
- P50579
- Entry Name:
- MAP2_HUMAN
- Status:
- reviewed
- Protein Names:
- Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M)
- Gene Names:
- METAP2 MNPEP P67EIF2
- Gene Names Primary:
- METAP2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 478
- Sequence:
- MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
- Catalytic Activity:
- Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
- Cofactor:
- COFACTOR: Name=Co(2+); Xref=ChEBI:CHEBI:48828;
- Cross Reference Drug Bank:
- DB00134 DB01422
- Gene Ontology Go:
- cytoplasm
cytosol
plasma membrane
aminopeptidase activity
metal ion binding
metalloaminopeptidase activity
metalloexopeptidase activity
poly(A) RNA binding
N-terminal protein amino acid modification
peptidyl-methionine modification
phototransduction, visible light
protein initiator methionine removal
protein processing
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway - Gene Ontology Biological Process:
- N-terminal protein amino acid modification
peptidyl-methionine modification
phototransduction, visible light
protein initiator methionine removal
protein processing
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway - Gene Ontology Molecular Function:
- aminopeptidase activity
metal ion binding
metalloaminopeptidase activity
metalloexopeptidase activity
poly(A) RNA binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
plasma membrane - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Aminopeptidase
Complete proteome
Cytoplasm
Direct protein sequencing
Glycoprotein
Hydrolase
Metal-binding
Phosphoprotein
Protease
Reference proteome