Names & Taxonomy

Uniprot ID:
P50281
Entry Name:
MMP14_HUMAN
Status:
reviewed
Protein Names:
Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)
Gene Names:
MMP14
Gene Names Primary:
MMP14
Organism:
Homo sapiens (Human)

Structure

Length:
582
Sequence:
MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.
Catalytic Activity:
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Active Site:
ACT_SITE 240 240
Cross Reference Drug Bank:
DB00786
Gene Ontology Go:
cytoplasmic vesicle
extracellular matrix
focal adhesion
Golgi lumen
integral component of plasma membrane
macropinosome
melanosome
plasma membrane
calcium ion binding
metalloendopeptidase activity
peptidase activator activity
zinc ion binding
angiogenesis
astrocyte cell migration
branching morphogenesis of an epithelial tube
chondrocyte proliferation
collagen catabolic process
craniofacial suture morphogenesis
embryonic cranial skeleton morphogenesis
endochondral ossification
endodermal cell differentiation
endothelial cell proliferation
extracellular matrix disassembly
extracellular matrix organization
lung development
male gonad development
negative regulation of focal adhesion assembly
negative regulation of Notch signaling pathway
ovarian follicle development
positive regulation of B cell differentiation
positive regulation of cell growth
positive regulation of cell migration
positive regulation of myotube differentiation
proteolysis
response to estrogen
response to hypoxia
response to mechanical stimulus
response to oxidative stress
tissue remodeling
zymogen activation
Gene Ontology Biological Process:
angiogenesis
astrocyte cell migration
branching morphogenesis of an epithelial tube
chondrocyte proliferation
collagen catabolic process
craniofacial suture morphogenesis
embryonic cranial skeleton morphogenesis
endochondral ossification
endodermal cell differentiation
endothelial cell proliferation
extracellular matrix disassembly
extracellular matrix organization
lung development
male gonad development
negative regulation of focal adhesion assembly
negative regulation of Notch signaling pathway
ovarian follicle development
positive regulation of B cell differentiation
positive regulation of cell growth
positive regulation of cell migration
positive regulation of myotube differentiation
proteolysis
response to estrogen
response to hypoxia
response to mechanical stimulus
response to oxidative stress
tissue remodeling
zymogen activation
Gene Ontology Molecular Function:
calcium ion binding
metalloendopeptidase activity
peptidase activator activity
zinc ion binding
Gene Ontology Cellular Component:
cytoplasmic vesicle
extracellular matrix
focal adhesion
Golgi lumen
integral component of plasma membrane
macropinosome
melanosome
plasma membrane
Keywords:
3D-structure
Calcium
Cleavage on pair of basic residues
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Disulfide bond
Hydrolase
Membrane
Metal-binding
Metalloprotease
Phosphoprotein
Polymorphism
Protease
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Zinc
Zymogen
Interacts With:
Q9BV57; P56945; Q8N6L0; Q9R064; P53667; P51884; P16035

Publication

PubMed ID:
8015608 7721107 7708715 7649159 8706726 14702039 12508121 15489334 8804434 12714657 17081065 18223680 20837484 21572390 22065321 25171405 9724659 22922033