Names & Taxonomy
- Uniprot ID:
- P50225
- Entry Name:
- ST1A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST)
- Gene Names:
- SULT1A1 STP STP1 OK/SW-cl.88
- Gene Names Orf:
- OK/SW-cl.88
- Gene Names Primary:
- SULT1A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 295
- Sequence:
- MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDFVVQHTSFKEMKKNPMTNYTTVPQEFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
- Catalytic Activity:
- 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
- Active Site:
- ACT_SITE 108 108 Proton acceptor.
- Cross Reference Drug Bank:
- DB00316 DB00675
- Gene Ontology Go:
- cytosol
aryl sulfotransferase activity
flavonol 3-sulfotransferase activity
steroid sulfotransferase activity
sulfotransferase activity
3'-phosphoadenosine 5'-phosphosulfate metabolic process
amine metabolic process
catecholamine metabolic process
estrogen metabolic process
flavonoid metabolic process
small molecule metabolic process
sulfation
xenobiotic metabolic process - Gene Ontology Biological Process:
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process
amine metabolic process
catecholamine metabolic process
estrogen metabolic process
flavonoid metabolic process
small molecule metabolic process
sulfation
xenobiotic metabolic process - Gene Ontology Molecular Function:
- aryl sulfotransferase activity
flavonol 3-sulfotransferase activity
steroid sulfotransferase activity
sulfotransferase activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Alternative splicing
Catecholamine metabolism
Complete proteome
Cytoplasm
Direct protein sequencing
Lipid metabolism
Phosphoprotein
Polymorphism
Reference proteome
Steroid metabolism
Transferase - Interacts With:
- O00204