Names & Taxonomy
- Uniprot ID:
- P50052
- Entry Name:
- AGTR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Type-2 angiotensin II receptor (Angiotensin II type-2 receptor) (AT2)
- Gene Names:
- AGTR2
- Gene Names Primary:
- AGTR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 363
- Sequence:
- MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
- Cross Reference Drug Bank:
- DB01349
- Gene Ontology Go:
- extracellular region
integral component of plasma membrane
perinuclear region of cytoplasm
plasma membrane
angiotensin type II receptor activity
peptide hormone binding
receptor antagonist activity
aldosterone secretion
angiotensin-activated signaling pathway
blood vessel remodeling
brain development
brain renin-angiotensin system
cell growth involved in cardiac muscle cell development
cell surface receptor signaling pathway
cellular response to dexamethasone stimulus
cellular sodium ion homeostasis
cerebellar cortex development
dopamine biosynthetic process
exploration behavior
extracellular negative regulation of signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
inflammatory response
intracellular signal transduction
negative regulation of blood vessel endothelial cell migration
negative regulation of cell growth
negative regulation of fibroblast proliferation
negative regulation of heart rate
negative regulation of icosanoid secretion
negative regulation of neurotrophin TRK receptor signaling pathway
negative regulation of norepinephrine secretion
nitric oxide mediated signal transduction
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of cell proliferation
positive regulation of cytokine secretion
positive regulation of extrinsic apoptotic signaling pathway
positive regulation of metanephric glomerulus development
positive regulation of nitric oxide biosynthetic process
positive regulation of nitric-oxide synthase activity
positive regulation of phosphoprotein phosphatase activity
positive regulation of renal sodium excretion
positive regulation of transcription, DNA-templated
positive regulation of vasodilation
regulation of blood pressure
regulation of metanephros size
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
regulation of transcription factor import into nucleus
renin-angiotensin regulation of aldosterone production
response to organonitrogen compound
vasodilation by angiotensin involved in regulation of systemic arterial blood pressure - Gene Ontology Biological Process:
- aldosterone secretion
angiotensin-activated signaling pathway
blood vessel remodeling
brain development
brain renin-angiotensin system
cell growth involved in cardiac muscle cell development
cell surface receptor signaling pathway
cellular response to dexamethasone stimulus
cellular sodium ion homeostasis
cerebellar cortex development
dopamine biosynthetic process
exploration behavior
extracellular negative regulation of signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
inflammatory response
intracellular signal transduction
negative regulation of blood vessel endothelial cell migration
negative regulation of cell growth
negative regulation of fibroblast proliferation
negative regulation of heart rate
negative regulation of icosanoid secretion
negative regulation of neurotrophin TRK receptor signaling pathway
negative regulation of norepinephrine secretion
nitric oxide mediated signal transduction
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of cell proliferation
positive regulation of cytokine secretion
positive regulation of extrinsic apoptotic signaling pathway
positive regulation of metanephric glomerulus development
positive regulation of nitric oxide biosynthetic process
positive regulation of nitric-oxide synthase activity
positive regulation of phosphoprotein phosphatase activity
positive regulation of renal sodium excretion
positive regulation of transcription, DNA-templated
positive regulation of vasodilation
regulation of blood pressure
regulation of metanephros size
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
regulation of transcription factor import into nucleus
renin-angiotensin regulation of aldosterone production
response to organonitrogen compound
vasodilation by angiotensin involved in regulation of systemic arterial blood pressure - Gene Ontology Molecular Function:
- angiotensin type II receptor activity
peptide hormone binding
receptor antagonist activity - Gene Ontology Cellular Component:
- extracellular region
integral component of plasma membrane
perinuclear region of cytoplasm
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P01019; P35625