Names & Taxonomy
- Uniprot ID:
- P49915
- Entry Name:
- GUAA_HUMAN
- Status:
- reviewed
- Protein Names:
- GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase)
- Gene Names:
- GMPS
- Gene Names Primary:
- GMPS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 693
- Sequence:
- MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.
- Pathway:
- Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.
- Catalytic Activity:
- ATP + XMP + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.
- Active Site:
- ACT_SITE 104 104 For GATase activity.
- Cross Reference Drug Bank:
- DB00130
- Gene Ontology Go:
- cytoplasm
cytosol
ATP binding
GMP synthase (glutamine-hydrolyzing) activity
GMP synthase activity
pyrophosphatase activity
glutamine metabolic process
nucleobase-containing small molecule metabolic process
purine nucleobase biosynthetic process
purine nucleobase metabolic process
purine ribonucleoside monophosphate biosynthetic process
small molecule metabolic process - Gene Ontology Biological Process:
- glutamine metabolic process
nucleobase-containing small molecule metabolic process
purine nucleobase biosynthetic process
purine nucleobase metabolic process
purine ribonucleoside monophosphate biosynthetic process
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
GMP synthase (glutamine-hydrolyzing) activity
GMP synthase activity
pyrophosphatase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Chromosomal rearrangement
Complete proteome
Cytoplasm
Direct protein sequencing
GMP biosynthesis
Glutamine amidotransferase
Ligase
Nucleotide-binding
Phosphoprotein
Proto-oncogene
Purine biosynthesis
Reference proteome