Names & Taxonomy

Uniprot ID:
P49902
Entry Name:
5NTC_HUMAN
Status:
reviewed
Protein Names:
Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (Cytosolic 5'-nucleotidase II)
Gene Names:
NT5C2 NT5B NT5CP PNT5
Gene Names Primary:
NT5C2
Organism:
Homo sapiens (Human)

Structure

Length:
561
Sequence:
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLVCAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTSCETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMKEVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLAPQEITHCHDEDDDEEEEEEEE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
Catalytic Activity:
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; ; Note=Binds 1 Mg(2+) ion per subunit.;
Enzyme Regulation:
ENZYME REGULATION: Allosterically activated by various compounds, including ATP.
Active Site:
ACT_SITE 52 52 Nucleophile.; ACT_SITE 54 54 Proton donor.
Cross Reference Drug Bank:
DB00171 DB00811
Gene Ontology Go:
cytosol
5'-nucleotidase activity
metal ion binding
nucleoside phosphotransferase activity
nucleotide binding
adenosine metabolic process
drug metabolic process
IMP metabolic process
nucleobase-containing small molecule metabolic process
phosphorylation
purine nucleobase metabolic process
purine nucleotide catabolic process
small molecule metabolic process
Gene Ontology Biological Process:
adenosine metabolic process
drug metabolic process
IMP metabolic process
nucleobase-containing small molecule metabolic process
phosphorylation
purine nucleobase metabolic process
purine nucleotide catabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
5'-nucleotidase activity
metal ion binding
nucleoside phosphotransferase activity
nucleotide binding
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
Allosteric enzyme
Alternative splicing
Complete proteome
Cytoplasm
Hereditary spastic paraplegia
Hydrolase
Magnesium
Metal-binding
Neurodegeneration
Nucleotide metabolism
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Interacts With:
P48047; P51116; Q7L9L4; Q86TA1; Q70IA8; Q9Y5B8; Q6ZVK8; O00560

Publication

PubMed ID:
7999131 14702039 15164054 15489334 18669648 21269460 24482476 17405878