Names & Taxonomy
- Uniprot ID:
- P49902
- Entry Name:
- 5NTC_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (Cytosolic 5'-nucleotidase II)
- Gene Names:
- NT5C2 NT5B NT5CP PNT5
- Gene Names Primary:
- NT5C2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 561
- Sequence:
- MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLVCAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTSCETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMKEVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLAPQEITHCHDEDDDEEEEEEEE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
- Catalytic Activity:
- A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; ; Note=Binds 1 Mg(2+) ion per subunit.;
- Enzyme Regulation:
- ENZYME REGULATION: Allosterically activated by various compounds, including ATP.
- Active Site:
- ACT_SITE 52 52 Nucleophile.; ACT_SITE 54 54 Proton donor.
- Cross Reference Drug Bank:
- DB00171 DB00811
- Gene Ontology Go:
- cytosol
5'-nucleotidase activity
metal ion binding
nucleoside phosphotransferase activity
nucleotide binding
adenosine metabolic process
drug metabolic process
IMP metabolic process
nucleobase-containing small molecule metabolic process
phosphorylation
purine nucleobase metabolic process
purine nucleotide catabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- adenosine metabolic process
drug metabolic process
IMP metabolic process
nucleobase-containing small molecule metabolic process
phosphorylation
purine nucleobase metabolic process
purine nucleotide catabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- 5'-nucleotidase activity
metal ion binding
nucleoside phosphotransferase activity
nucleotide binding - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Allosteric enzyme
Alternative splicing
Complete proteome
Cytoplasm
Hereditary spastic paraplegia
Hydrolase
Magnesium
Metal-binding
Neurodegeneration
Nucleotide metabolism
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- P48047; P51116; Q7L9L4; Q86TA1; Q70IA8; Q9Y5B8; Q6ZVK8; O00560