Names & Taxonomy
- Uniprot ID:
- P49773
- Entry Name:
- HINT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Histidine triad nucleotide-binding protein 1 (EC 3.-.-.-) (Adenosine 5'-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)
- Gene Names:
- HINT1 HINT PKCI1 PRKCNH1
- Gene Names Primary:
- HINT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 126
- Sequence:
- MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus. Note=Interaction with CDK7 leads to a more nuclear localization.
Function
- Function:
- Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.
- Active Site:
- ACT_SITE 112 112 Tele-AMP-histidine intermediate.
- Cross Reference Drug Bank:
- DB00131
- Gene Ontology Go:
- cytoplasm
cytoskeleton
extracellular exosome
histone deacetylase complex
nucleus
plasma membrane
hydrolase activity
nucleotide binding
protein kinase C binding
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of calcium-mediated signaling
purine ribonucleotide catabolic process
regulation of transcription, DNA-templated
signal transduction
transcription, DNA-templated - Gene Ontology Biological Process:
- intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of calcium-mediated signaling
purine ribonucleotide catabolic process
regulation of transcription, DNA-templated
signal transduction
transcription, DNA-templated - Gene Ontology Molecular Function:
- hydrolase activity
nucleotide binding
protein kinase C binding - Gene Ontology Cellular Component:
- cytoplasm
cytoskeleton
extracellular exosome
histone deacetylase complex
nucleus
plasma membrane - Keywords:
- 3D-structure
Acetylation
Apoptosis
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Hydrolase
Neuropathy
Nucleotide-binding
Nucleus
Phosphoprotein
Reference proteome
Transcription
Transcription regulation