Names & Taxonomy
- Uniprot ID:
- P49619
- Entry Name:
- DGKG_HUMAN
- Status:
- reviewed
- Protein Names:
- Diacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma)
- Gene Names:
- DGKG DAGK3
- Gene Names Primary:
- DGKG
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 791
- Sequence:
- MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Membrane. Note=Can be loosely bound to the membranes.
Function
- Function:
- Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid.
- Catalytic Activity:
- ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Requires phosphatidylserine for maximal activity.
- Cross Reference Drug Bank:
- DB00144
- Gene Ontology Go:
- cytoplasm
plasma membrane
ATP binding
calcium ion binding
diacylglycerol kinase activity
blood coagulation
intracellular signal transduction
neuron development
platelet activation
protein kinase C-activating G-protein coupled receptor signaling pathway
signal transduction - Gene Ontology Biological Process:
- blood coagulation
intracellular signal transduction
neuron development
platelet activation
protein kinase C-activating G-protein coupled receptor signaling pathway
signal transduction - Gene Ontology Molecular Function:
- ATP binding
calcium ion binding
diacylglycerol kinase activity - Gene Ontology Cellular Component:
- cytoplasm
plasma membrane - Keywords:
- ATP-binding
Alternative splicing
Calcium
Complete proteome
Cytoplasm
Kinase
Membrane
Metal-binding
Nucleotide-binding
Polymorphism
Reference proteome
Repeat
Transferase
Zinc
Zinc-finger