Names & Taxonomy
- Uniprot ID:
- P49585
- Entry Name:
- PCY1A_HUMAN
- Status:
- reviewed
- Protein Names:
- Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A)
- Gene Names:
- PCYT1A CTPCT PCYT1
- Gene Names Primary:
- PCYT1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 367
- Sequence:
- MDAQCSAKVNARKRRKEAPGPNGATEEDGVPSKVQRCAVGLRQPAPFSDEIEVDFSKPYVRVTMEEASRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTRERSPSPSFRWPFSGKTSPPCSPANLSRHKAAAYDISEDEED
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytosol
Function
- Function:
- Controls phosphatidylcholine synthesis.
- Pathway:
- Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.
- Catalytic Activity:
- CTP + phosphocholine = diphosphate + CDP-choline.
- Enzyme Regulation:
- ENZYME REGULATION: By phosphorylation.
- Cross Reference Drug Bank:
- DB00122 DB00709
- Gene Ontology Go:
- cytosol
endoplasmic reticulum membrane
glycogen granule
choline-phosphate cytidylyltransferase activity
lipid binding
CDP-choline pathway
glycerophospholipid biosynthetic process
phosphatidylcholine biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- CDP-choline pathway
glycerophospholipid biosynthetic process
phosphatidylcholine biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- choline-phosphate cytidylyltransferase activity
lipid binding - Gene Ontology Cellular Component:
- cytosol
endoplasmic reticulum membrane
glycogen granule - Keywords:
- Acetylation
Complete proteome
Cone-rod dystrophy
Cytoplasm
Disease mutation
Dwarfism
Lipid biosynthesis
Lipid metabolism
Membrane
Nucleotidyltransferase
Phospholipid biosynthesis
Phospholipid metabolism
Phosphoprotein
Reference proteome
Repeat
Transferase
Ubl conjugation