Names & Taxonomy
- Uniprot ID:
- P49366
- Entry Name:
- DHYS_HUMAN
- Status:
- reviewed
- Protein Names:
- Deoxyhypusine synthase (DHS) (EC 2.5.1.46)
- Gene Names:
- DHPS DS
- Gene Names Primary:
- DHPS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 369
- Sequence:
- MEGSLEREAPAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFGRAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFEDWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMDAFMHEKNED
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
- Pathway:
- Protein modification; eIF5A hypusination.
- Catalytic Activity:
- -lysine + spermidine = -deoxyhypusine + propane-1,3-diamine.
- Cofactor:
- COFACTOR: Name=NAD(+); Xref=ChEBI:CHEBI:57540;
- Active Site:
- ACT_SITE 329 329 Nucleophile.
- Gene Ontology Go:
- cytosol
deoxyhypusine synthase activity
cellular protein metabolic process
deoxyhypusine biosynthetic process from spermidine
glucose homeostasis
peptidyl-lysine modification to peptidyl-hypusine
positive regulation of cell proliferation
positive regulation of T cell proliferation
post-translational protein modification
protein homotetramerization
translation - Gene Ontology Biological Process:
- cellular protein metabolic process
deoxyhypusine biosynthetic process from spermidine
glucose homeostasis
peptidyl-lysine modification to peptidyl-hypusine
positive regulation of cell proliferation
positive regulation of T cell proliferation
post-translational protein modification
protein homotetramerization
translation - Gene Ontology Molecular Function:
- deoxyhypusine synthase activity
- Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Hypusine biosynthesis
NAD
Phosphoprotein
Polymorphism
Reference proteome
Transferase - Interacts With:
- P63241; Q9GZV4; P27361; Q9GZT8; Q6ZVK8; Q9HD43; O00194; Q04864; P32969; Q7L8A9; Q96HA8; P52744-2