Names & Taxonomy
- Uniprot ID:
- P49356
- Entry Name:
- FNTB_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta)
- Gene Names:
- FNTB
- Gene Names Primary:
- FNTB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 437
- Sequence:
- MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFEELKDETSAEPATD
- Proteomes:
- UP000005640
Function
- Function:
- Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
- Catalytic Activity:
- Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Gene Ontology Go:
- cytosol
microtubule associated complex
protein farnesyltransferase complex
drug binding
farnesyltranstransferase activity
isoprenoid binding
peptide binding
protein farnesyltransferase activity
zinc ion binding
negative regulation of cell proliferation
phototransduction, visible light
positive regulation of cell cycle
positive regulation of fibroblast proliferation
positive regulation of nitric-oxide synthase biosynthetic process
protein farnesylation
regulation of rhodopsin mediated signaling pathway
response to cytokine
response to inorganic substance
response to organic cyclic compound
rhodopsin mediated signaling pathway
wound healing - Gene Ontology Biological Process:
- negative regulation of cell proliferation
phototransduction, visible light
positive regulation of cell cycle
positive regulation of fibroblast proliferation
positive regulation of nitric-oxide synthase biosynthetic process
protein farnesylation
regulation of rhodopsin mediated signaling pathway
response to cytokine
response to inorganic substance
response to organic cyclic compound
rhodopsin mediated signaling pathway
wound healing - Gene Ontology Molecular Function:
- drug binding
farnesyltranstransferase activity
isoprenoid binding
peptide binding
protein farnesyltransferase activity
zinc ion binding - Gene Ontology Cellular Component:
- cytosol
microtubule associated complex
protein farnesyltransferase complex - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Metal-binding
Phosphoprotein
Prenyltransferase
Reference proteome
Repeat
Transferase
Zinc - Interacts With:
- P49354