Names & Taxonomy

Uniprot ID:
P49354
Entry Name:
FNTA_HUMAN
Status:
reviewed
Protein Names:
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha)
Gene Names:
FNTA
Gene Names Primary:
FNTA
Organism:
Homo sapiens (Human)

Structure

Length:
379
Sequence:
MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSPTNVQQ
Proteomes:
UP000005640

Function

Function:
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.
Catalytic Activity:
Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
Enzyme Regulation:
ENZYME REGULATION: Activated by the AGRIN-induced phosphorylation which is mediated by MUSK.
Gene Ontology Go:
CAAX-protein geranylgeranyltransferase complex
cytoplasm
cytosol
microtubule associated complex
protein farnesyltransferase complex
acetylcholine receptor regulator activity
alpha-tubulin binding
CAAX-protein geranylgeranyltransferase activity
microtubule binding
protein farnesyltransferase activity
protein geranylgeranyltransferase activity
Rab geranylgeranyltransferase activity
apoptotic process
cellular component disassembly involved in execution phase of apoptosis
neurotransmitter receptor metabolic process
phototransduction, visible light
positive regulation of deacetylase activity
positive regulation of tubulin deacetylation
programmed cell death
protein farnesylation
protein geranylgeranylation
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway
skeletal muscle acetylcholine-gated channel clustering
transforming growth factor beta receptor signaling pathway
Gene Ontology Biological Process:
apoptotic process
cellular component disassembly involved in execution phase of apoptosis
neurotransmitter receptor metabolic process
phototransduction, visible light
positive regulation of deacetylase activity
positive regulation of tubulin deacetylation
programmed cell death
protein farnesylation
protein geranylgeranylation
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway
skeletal muscle acetylcholine-gated channel clustering
transforming growth factor beta receptor signaling pathway
Gene Ontology Molecular Function:
acetylcholine receptor regulator activity
alpha-tubulin binding
CAAX-protein geranylgeranyltransferase activity
microtubule binding
protein farnesyltransferase activity
protein geranylgeranyltransferase activity
Rab geranylgeranyltransferase activity
Gene Ontology Cellular Component:
CAAX-protein geranylgeranyltransferase complex
cytoplasm
cytosol
microtubule associated complex
protein farnesyltransferase complex
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Phosphoprotein
Prenyltransferase
Reference proteome
Repeat
Transferase
Interacts With:
P49356

Publication

PubMed ID:
8276393 8419339 8494894 14702039 16421571 15489334 17974005 16964243 18669648 19413330 20068231 21269460 21406692 11687658 12036349 12825937 15170324 15451670 16893176 19246009