Names & Taxonomy
- Uniprot ID:
- P48651
- Entry Name:
- PTSS1_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I)
- Gene Names:
- PTDSS1 KIAA0024 PSSA
- Gene Names Primary:
- PTDSS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 473
- Sequence:
- MASCVGSRTLSKDDVNYKMHFRMINEQQVEDITIDFFYRPHTITLLSFTIVSLMYFAFTRDDSVPEDNIWRGILSVIFFFLIISVLAFPNGPFTRPHPALWRMVFGLSVLYFLFLVFLLFLNFEQVKSLMYWLDPNLRYATREADVMEYAVNCHVITWERIISHFDIFAFGHFWGWAMKALLIRSYGLCWTISITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMVVCRFLEMRTYHWASFKDIHTTTGKIKRAVLQFTPASWTYVRWFDPKSSFQRVAGVYLFMIIWQLTELNTFFLKHIFVFQASHPLSWGRILFIGGITAPTVRQYYAYLTDTQCKRVGTQCWVFGVIGFLEAIVCIKFGQDLFSKTQILYVVLWLLCVAFTTFLCLYGMIWYAEHYGHREKTYSECEDGTYSPEISWHHRKGTKGSEDSPPKHAGNNESHSSRRRNRHSKSKVTNGVGKK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.
- Pathway:
- Phospholipid metabolism; phosphatidylserine biosynthesis.
- Catalytic Activity:
- L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=67 uM for serine (in the presence of 2 mM PC)
- Enzyme Regulation:
- ENZYME REGULATION: Requires calcium ions. Activated by exogenous phosphatidylethanolamine.
- Cross Reference Drug Bank:
- DB00144
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
membrane
transferase activity
glycerophospholipid biosynthetic process
phosphatidylserine biosynthetic process
phospholipid biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- glycerophospholipid biosynthetic process
phosphatidylserine biosynthetic process
phospholipid biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- transferase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
membrane - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Disease mutation
Dwarfism
Endoplasmic reticulum
Lipid biosynthesis
Lipid metabolism
Membrane
Mental retardation
Phospholipid biosynthesis
Phospholipid metabolism
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix