Names & Taxonomy
- Uniprot ID:
- P48549
- Entry Name:
- KCNJ3_HUMAN
- Status:
- reviewed
- Protein Names:
- G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3)
- Gene Names:
- KCNJ3 GIRK1
- Gene Names Primary:
- KCNJ3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 501
- Sequence:
- MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGAARMEGNLPAKLRKMNSDRFT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
- Intramembrane:
- INTRAMEM 130 141 Helical; Pore-forming; Name=H5.
Function
- Function:
- This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
- Cross Reference Drug Bank:
- DB00898 DB01159
- Gene Ontology Go:
- external side of plasma membrane
plasma membrane
T-tubule
voltage-gated potassium channel complex
G-protein activated inward rectifier potassium channel activity
potassium ion import
potassium ion transport
response to electrical stimulus
synaptic transmission - Gene Ontology Biological Process:
- potassium ion import
potassium ion transport
response to electrical stimulus
synaptic transmission - Gene Ontology Molecular Function:
- G-protein activated inward rectifier potassium channel activity
- Gene Ontology Cellular Component:
- external side of plasma membrane
plasma membrane
T-tubule
voltage-gated potassium channel complex - Keywords:
- Alternative splicing
Complete proteome
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Potassium
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel