Names & Taxonomy

Uniprot ID:
P48544
Entry Name:
KCNJ5_HUMAN
Status:
reviewed
Protein Names:
G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (IRK-4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)
Gene Names:
KCNJ5 GIRK4
Gene Names Primary:
KCNJ5
Organism:
Homo sapiens (Human)

Structure

Length:
419
Sequence:
MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKCNVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDHVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.
Intramembrane:
INTRAMEM 136 147 Helical; Pore-forming; Name=H5.

Function

Function:
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
Cross Reference Drug Bank:
DB00898 DB01016
Gene Ontology Go:
external side of plasma membrane
plasma membrane
T-tubule
voltage-gated potassium channel complex
G-protein activated inward rectifier potassium channel activity
potassium ion import
potassium ion transport
synaptic transmission
Gene Ontology Biological Process:
potassium ion import
potassium ion transport
synaptic transmission
Gene Ontology Molecular Function:
G-protein activated inward rectifier potassium channel activity
Gene Ontology Cellular Component:
external side of plasma membrane
plasma membrane
T-tubule
voltage-gated potassium channel complex
Keywords:
Complete proteome
Disease mutation
Ion channel
Ion transport
Long QT syndrome
Membrane
Polymorphism
Potassium
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel

Publication

PubMed ID:
8047164 8524415 8558261 10659995 8834003 14702039 16554811 15489334 21311022 20560207 22203740 22275527 22848660 22308486