Names & Taxonomy
- Uniprot ID:
- P48449
- Entry Name:
- ERG7_HUMAN
- Status:
- reviewed
- Protein Names:
- Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC) (hOSC)
- Gene Names:
- LSS OSC
- Gene Names Primary:
- LSS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 732
- Sequence:
- MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDTKNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFSQLYPERALAGHP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
- Pathway:
- Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3.
- Catalytic Activity:
- (3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol.
- Active Site:
- ACT_SITE 232 232 Proton acceptor.; ACT_SITE 455 455 Proton donor.
- Gene Ontology Go:
- endoplasmic reticulum membrane
lipid particle
membrane
lanosterol synthase activity
cholesterol biosynthetic process
regulation of protein stability
small molecule metabolic process
steroid biosynthetic process - Gene Ontology Biological Process:
- cholesterol biosynthetic process
regulation of protein stability
small molecule metabolic process
steroid biosynthetic process - Gene Ontology Molecular Function:
- lanosterol synthase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
lipid particle
membrane - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Cataract
Complete proteome
Direct protein sequencing
Disease mutation
Endoplasmic reticulum
Isomerase
Lipid biosynthesis
Lipid metabolism
Membrane
Polymorphism
Reference proteome
Repeat
Steroid biosynthesis