Names & Taxonomy
- Uniprot ID:
- P48039
- Entry Name:
- MTR1A_HUMAN
- Status:
- reviewed
- Protein Names:
- Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)
- Gene Names:
- MTNR1A
- Gene Names Primary:
- MTNR1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 350
- Sequence:
- MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
- Cross Reference Drug Bank:
- DB06594 DB01065 DB00980 DB09071
- Gene Ontology Go:
- integral component of plasma membrane
neuronal cell body
plasma membrane
receptor complex
hormone binding
melatonin receptor activity
organic cyclic compound binding
aging
camera-type eye development
cell surface receptor signaling pathway
circadian rhythm
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
mating behavior
negative regulation of insulin secretion
positive regulation of cGMP biosynthetic process - Gene Ontology Biological Process:
- aging
camera-type eye development
cell surface receptor signaling pathway
circadian rhythm
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
mating behavior
negative regulation of insulin secretion
positive regulation of cGMP biosynthetic process - Gene Ontology Molecular Function:
- hormone binding
melatonin receptor activity
organic cyclic compound binding - Gene Ontology Cellular Component:
- integral component of plasma membrane
neuronal cell body
plasma membrane
receptor complex - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P49286; O76081