Names & Taxonomy
- Uniprot ID:
- P48029
- Entry Name:
- SC6A8_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8)
- Gene Names:
- SLC6A8
- Gene Names Primary:
- SLC6A8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 635
- Sequence:
- MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Required for the uptake of creatine in muscles and brain.
- Cross Reference Drug Bank:
- DB00148
- Gene Ontology Go:
- integral component of membrane
integral component of plasma membrane
plasma membrane
creatine transmembrane transporter activity
creatine:sodium symporter activity
neurotransmitter:sodium symporter activity
cellular nitrogen compound metabolic process
creatine metabolic process
creatine transmembrane transport
creatine transport
muscle contraction
polyamine metabolic process
small molecule metabolic process
transport - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
creatine metabolic process
creatine transmembrane transport
creatine transport
muscle contraction
polyamine metabolic process
small molecule metabolic process
transport - Gene Ontology Molecular Function:
- creatine:sodium symporter activity
creatine transmembrane transporter activity
neurotransmitter:sodium symporter activity - Gene Ontology Cellular Component:
- integral component of membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Glycoprotein
Ion transport
Membrane
Mental retardation
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport