Names & Taxonomy
- Uniprot ID:
- P47897
- Entry Name:
- SYQ_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS)
- Gene Names:
- QARS
- Gene Names Primary:
- QARS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 775
- Sequence:
- MAALDSLSLFTSLGLSEQKARETLKNSALSAQLREAATQAQQTLGSTIDKATGILLYGLASRLRDTRRLSFLVSYIASKKIHTEPQLSAALEYVRSHPLDPIDTVDFERECGVGVIVTPEQIEEAVEAAINRHRPQLLVERYHFNMGLLMGEARAVLKWADGKMIKNEVDMQVLHLLGPKLEADLEKKFKVAKARLEETDRRTAKDVVENGETADQTLSLMEQLRGEALKFHKPGENYKTPGYVVTPHTMNLLKQHLEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFLRFDDTNPEKEEAKFFTAICDMVAWLGYTPYKVTYASDYFDQLYAWAVELIRRGLAYVCHQRGEELKGHNTLPSPWRDRPMEESLLLFEAMRKGKFSEGEATLRMKLVMEDGKMDPVAYRVKYTPHHRTGDKWCIYPTYDYTHCLCDSIEHITHSLCTKEFQARRSSYFWLCNALDVYCPVQWEYGRLNLHYAVVSKRKILQLVATGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLESLRVIITNFPAAKSLDIQVPNFPADETKGFHQVPFAPIVFIERTDFKEEPEPGFKRLAWGQPVGLRHTGYVIELQHVVKGPSGCVESLEVTCRRADAGEKPKAFIHWVSQPLMCEVRLYERLFQHKNPEDPTEVPGGFLSDLNLASLHVVDAALVDCSVALAKPFDKFQFERLGYFSVDPDSHQGKLVFNRTVTLKEDPGKV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Plays a critical role in brain development.
- Catalytic Activity:
- ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).
- Cross Reference Drug Bank:
- DB00130
- Gene Ontology Go:
- cytoplasm
cytosol
mitochondrial matrix
ATP binding
glutamine-tRNA ligase activity
brain development
cellular nitrogen compound metabolic process
gene expression
glutaminyl-tRNA aminoacylation
selenium compound metabolic process
small molecule metabolic process
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- brain development
cellular nitrogen compound metabolic process
gene expression
glutaminyl-tRNA aminoacylation
selenium compound metabolic process
small molecule metabolic process
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- ATP binding
glutamine-tRNA ligase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
mitochondrial matrix - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Epilepsy
Ligase
Nucleotide-binding
Phosphoprotein
Primary microcephaly
Protein biosynthesis
Reference proteome - Interacts With:
- Q08117; Q86UW9; Q6P597; Q9BRK4; Q99081; Q9BUZ4; Q15645; Q9H9H4