Names & Taxonomy

Uniprot ID:
P47870
Entry Name:
GBRB2_HUMAN
Status:
reviewed
Protein Names:
Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2)
Gene Names:
GABRB2
Gene Names Primary:
GABRB2
Organism:
Homo sapiens (Human)

Structure

Length:
512
Sequence:
MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKIFYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Function

Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Cross Reference Drug Bank:
DB00659 DB00546 DB00404 DB00543 DB01558 DB00237 DB00241 DB00475 DB01594 DB00349 DB01068 DB00628 DB01559 DB01189 DB00829 DB00228 DB01049 DB01215 DB00402 DB00898 DB00189 DB00292 DB01567 DB01205 DB00690 DB06716 DB01381 DB01437 DB00801 DB01159 DB00753 DB00186 DB00371 DB01028 DB01107 DB00683 DB01595 DB00334 DB00842 DB00312 DB01588 DB00794 DB00818 DB01589 DB01236 DB00306 DB00231 DB00273 DB00897
Gene Ontology Go:
cell junction
chloride channel complex
cytosol
extracellular exosome
GABA-A receptor complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane
chloride channel activity
GABA-A receptor activity
inhibitory extracellular ligand-gated ion channel activity
cellular response to histamine
chloride transmembrane transport
cochlea development
gamma-aminobutyric acid signaling pathway
inner ear receptor cell development
innervation
ion transmembrane transport
negative regulation of neuron apoptotic process
sensory perception of sound
synaptic transmission
synaptic transmission, GABAergic
transmembrane transport
transport
Gene Ontology Biological Process:
cellular response to histamine
chloride transmembrane transport
cochlea development
gamma-aminobutyric acid signaling pathway
inner ear receptor cell development
innervation
ion transmembrane transport
negative regulation of neuron apoptotic process
sensory perception of sound
synaptic transmission
synaptic transmission, GABAergic
transmembrane transport
transport
Gene Ontology Molecular Function:
chloride channel activity
GABA-A receptor activity
inhibitory extracellular ligand-gated ion channel activity
Gene Ontology Cellular Component:
cell junction
chloride channel complex
cytosol
extracellular exosome
GABA-A receptor complex
integral component of plasma membrane
plasma membrane
postsynaptic membrane
Keywords:
Alternative splicing
Cell junction
Cell membrane
Chloride
Chloride channel
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Isopeptide bond
Ligand-gated ion channel
Membrane
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport
Ubl conjugation

Publication

PubMed ID:
8264558 7707873 19763268 14702039 15489334 16983389 17370265