Names & Taxonomy

Uniprot ID:
P46976
Entry Name:
GLYG_HUMAN
Status:
reviewed
Protein Names:
Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186)
Gene Names:
GYG1 GYG
Gene Names Primary:
GYG1
Organism:
Homo sapiens (Human)

Structure

Length:
350
Sequence:
MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ
Proteomes:
UP000005640

Function

Function:
Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
Pathway:
Glycan biosynthesis; glycogen biosynthesis.
Catalytic Activity:
UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin.
Cofactor:
COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; ; Note=Divalent metal ions. Required for self-glucosylation. Manganese is the most effective.;
Active Site:
ACT_SITE 86 86
Gene Ontology Go:
cytosol
extracellular exosome
lysosomal lumen
membrane
glycogenin glucosyltransferase activity
metal ion binding
carbohydrate metabolic process
glucose metabolic process
glycogen biosynthetic process
glycogen catabolic process
small molecule metabolic process
Gene Ontology Biological Process:
carbohydrate metabolic process
glucose metabolic process
glycogen biosynthetic process
glycogen catabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
glycogenin glucosyltransferase activity
metal ion binding
Gene Ontology Cellular Component:
cytosol
extracellular exosome
lysosomal lumen
membrane
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Glycogen biosynthesis
Glycogen storage disease
Glycoprotein
Manganese
Metal-binding
Phosphoprotein
Reference proteome
Transferase
Interacts With:
P13807

Publication

PubMed ID:
8602861 8661012 10395894 10721716 16641997 15489334 17055998 19413330 21269460 22223895 25272951 20357282