Names & Taxonomy
- Uniprot ID:
- P46976
- Entry Name:
- GLYG_HUMAN
- Status:
- reviewed
- Protein Names:
- Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186)
- Gene Names:
- GYG1 GYG
- Gene Names Primary:
- GYG1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 350
- Sequence:
- MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ
- Proteomes:
- UP000005640
Function
- Function:
- Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
- Pathway:
- Glycan biosynthesis; glycogen biosynthesis.
- Catalytic Activity:
- UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin.
- Cofactor:
- COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; ; Note=Divalent metal ions. Required for self-glucosylation. Manganese is the most effective.;
- Active Site:
- ACT_SITE 86 86
- Gene Ontology Go:
- cytosol
extracellular exosome
lysosomal lumen
membrane
glycogenin glucosyltransferase activity
metal ion binding
carbohydrate metabolic process
glucose metabolic process
glycogen biosynthetic process
glycogen catabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
glucose metabolic process
glycogen biosynthetic process
glycogen catabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- glycogenin glucosyltransferase activity
metal ion binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
lysosomal lumen
membrane - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Glycogen biosynthesis
Glycogen storage disease
Glycoprotein
Manganese
Metal-binding
Phosphoprotein
Reference proteome
Transferase - Interacts With:
- P13807