Names & Taxonomy
- Uniprot ID:
- P46721
- Entry Name:
- SO1A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier organic anion transporter family member 1A2 (OATP-A) (Organic anion-transporting polypeptide 1) (OATP-1) (Sodium-independent organic anion transporter) (Solute carrier family 21 member 3)
- Gene Names:
- SLCO1A2 OATP OATP1 OATP1A2 SLC21A3
- Gene Names Primary:
- SLCO1A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 670
- Sequence:
- MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLRKCHLPGENASSGTELIETKVKGKENECKDIYQKSTVLKDDELKTKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
- Cross Reference Drug Bank:
- DB00345 DB01076 DB00887 DB00291 DB02659 DB00286 DB00091 DB03619 DB01234 DB01396 DB00390 DB00917 DB00584 DB00199 DB00783 DB04573 DB00655 DB00950 DB01016 DB00741 DB01050 DB00224 DB00328 DB01026 DB01009 DB00451 DB00279 DB01583 DB00227 DB00563 DB06710 DB08893 DB01183 DB00788 DB00220 DB01092 DB00175 DB00860 DB00635 DB01032 DB00908 DB00468 DB01045 DB00503 DB00728 DB01098 DB01232 DB00641 DB00421 DB00669 DB08834 DB00624 DB01124 DB01586 DB00661
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
bile acid transmembrane transporter activity
organic anion transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity
bile acid and bile salt transport
bile acid metabolic process
mitophagy in response to mitochondrial depolarization
organic anion transport
small molecule metabolic process
sodium-independent organic anion transport
transmembrane transport - Gene Ontology Biological Process:
- bile acid and bile salt transport
bile acid metabolic process
mitophagy in response to mitochondrial depolarization
organic anion transport
small molecule metabolic process
sodium-independent organic anion transport
transmembrane transport - Gene Ontology Molecular Function:
- bile acid transmembrane transporter activity
organic anion transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport