Names & Taxonomy

Uniprot ID:
P46531
Entry Name:
NOTC1_HUMAN
Status:
reviewed
Protein Names:
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene Names:
NOTCH1 TAN1
Gene Names Primary:
NOTCH1
Organism:
Homo sapiens (Human)

Structure

Length:
2555
Sequence:
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYYGREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLEIDNRQCVQASSQCFQSATDVAAFLGALASLGSLNIPYKIEAVQSETVEPPPPAQLHFMYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKNASDGALMDDNQNEWGDEDLETKKFRFEEPVVLPDLDDQTDHRQWTQQHLDAADLRMSAMAPTPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNREETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNLVRSPQLHGAPLGGTPTLSPPLCSPNGYLGSLKPGVQGKKVRKPSSKGLACGSKEAKDLKARRKKSQDGKGCLLDSSGMLSPVDSLESPHGYLSDVASPPLLPSPFQQSPSVPLNHLPGMPDTHLGIGHLNVAAKPEMAALGGGGRLAFETGPPRLSHLPVASGTSTVLGSSSGGALNFTVGGSTSLNGQCEWLSRLQSGMVPNQYNPLRGSVAPGPLSTQAPSLQHGMVGPLHSSLAASALSQMMSYQGLPSTRLATQPHLVQTQQVQPQNLQMQQQNLQPANIQQQQSLQPPPPPPQPHLGVSSAASGHLGRSFLSGEPSQADVQPLGPSSLAVHTILPQESPALPTSLPSSLVPPVTAAQFLTPPSQHSYSSPVDNTPSHQLQVPEHPFLTPSPESPDQWSSSSPHSNVSDWSEGVSSPPTSMQSQIARIPEAFK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
Gene Ontology Go:
acrosomal vesicle
adherens junction
apical plasma membrane
cell surface
cytosol
endoplasmic reticulum membrane
extracellular region
Golgi membrane
integral component of membrane
MAML1-RBP-Jkappa- ICN1 complex
nucleoplasm
nucleus
plasma membrane
receptor complex
calcium ion binding
chromatin DNA binding
core promoter binding
enzyme binding
enzyme inhibitor activity
receptor activity
sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription factor binding
aortic valve morphogenesis
apoptotic process involved in embryonic digit morphogenesis
arterial endothelial cell differentiation
astrocyte differentiation
atrioventricular node development
atrioventricular valve morphogenesis
auditory receptor cell fate commitment
axonogenesis
branching morphogenesis of an epithelial tube
cardiac atrium morphogenesis
cardiac chamber formation
cardiac epithelial to mesenchymal transition
cardiac left ventricle morphogenesis
cardiac muscle cell proliferation
cardiac muscle tissue morphogenesis
cardiac right atrium morphogenesis
cardiac right ventricle formation
cardiac septum morphogenesis
cardiac vascular smooth muscle cell development
cardiac ventricle morphogenesis
cell differentiation in spinal cord
cell fate specification
cell migration involved in endocardial cushion formation
cellular response to follicle-stimulating hormone stimulus
cellular response to vascular endothelial growth factor stimulus
cilium morphogenesis
collecting duct development
compartment pattern specification
coronary artery morphogenesis
coronary vein morphogenesis
determination of left/right symmetry
distal tubule development
embryonic hindlimb morphogenesis
endocardial cell differentiation
endocardial cushion morphogenesis
endocardium development
endocardium morphogenesis
endoderm development
epithelial to mesenchymal transition
epithelial to mesenchymal transition involved in endocardial cushion formation
forebrain development
foregut morphogenesis
gene expression
glomerular mesangial cell development
growth involved in heart morphogenesis
hair follicle morphogenesis
heart development
heart looping
heart trabecula morphogenesis
humoral immune response
immune response
in utero embryonic development
inflammatory response to antigenic stimulus
interleukin-4 secretion
keratinocyte differentiation
left/right axis specification
liver development
lung development
mesenchymal cell development
mitral valve formation
negative regulation of anoikis
negative regulation of auditory receptor cell differentiation
negative regulation of BMP signaling pathway
negative regulation of calcium ion-dependent exocytosis
negative regulation of canonical Wnt signaling pathway
negative regulation of catalytic activity
negative regulation of cell migration involved in sprouting angiogenesis
negative regulation of cell proliferation
negative regulation of cell-substrate adhesion
negative regulation of endothelial cell chemotaxis
negative regulation of glial cell proliferation
negative regulation of myoblast differentiation
negative regulation of myotube differentiation
negative regulation of neurogenesis
negative regulation of oligodendrocyte differentiation
negative regulation of ossification
negative regulation of osteoblast differentiation
negative regulation of photoreceptor cell differentiation
negative regulation of pro-B cell differentiation
negative regulation of stem cell differentiation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
neural tube development
neuronal stem cell population maintenance
Notch receptor processing
Notch signaling involved in heart development
Notch signaling pathway
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
oligodendrocyte differentiation
organ regeneration
pericardium morphogenesis
positive regulation of apoptotic process
positive regulation of astrocyte differentiation
positive regulation of BMP signaling pathway
positive regulation of cardiac muscle cell proliferation
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of endothelial cell differentiation
positive regulation of epithelial cell proliferation
positive regulation of epithelial to mesenchymal transition
positive regulation of JAK-STAT cascade
positive regulation of keratinocyte differentiation
positive regulation of neuroblast proliferation
positive regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
positive regulation of transcription of Notch receptor target
positive regulation of transcription, DNA-templated
positive regulation of viral genome replication
positive regulation of viral transcription
prostate gland epithelium morphogenesis
pulmonary valve morphogenesis
regulation of epithelial cell proliferation involved in prostate gland development
regulation of extracellular matrix assembly
regulation of somitogenesis
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
regulation of transcription, DNA-templated
response to corticosteroid
response to lipopolysaccharide
response to muramyl dipeptide
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
skeletal muscle cell differentiation
somatic stem cell division
spermatogenesis
sprouting angiogenesis
tissue regeneration
transcription initiation from RNA polymerase II promoter
tube formation
vasculogenesis involved in coronary vascular morphogenesis
venous endothelial cell differentiation
ventricular septum morphogenesis
ventricular trabecula myocardium morphogenesis
Gene Ontology Biological Process:
aortic valve morphogenesis
apoptotic process involved in embryonic digit morphogenesis
arterial endothelial cell differentiation
astrocyte differentiation
atrioventricular node development
atrioventricular valve morphogenesis
auditory receptor cell fate commitment
axonogenesis
branching morphogenesis of an epithelial tube
cardiac atrium morphogenesis
cardiac chamber formation
cardiac epithelial to mesenchymal transition
cardiac left ventricle morphogenesis
cardiac muscle cell proliferation
cardiac muscle tissue morphogenesis
cardiac right atrium morphogenesis
cardiac right ventricle formation
cardiac septum morphogenesis
cardiac vascular smooth muscle cell development
cardiac ventricle morphogenesis
cell differentiation in spinal cord
cell fate specification
cell migration involved in endocardial cushion formation
cellular response to follicle-stimulating hormone stimulus
cellular response to vascular endothelial growth factor stimulus
cilium morphogenesis
collecting duct development
compartment pattern specification
coronary artery morphogenesis
coronary vein morphogenesis
determination of left/right symmetry
distal tubule development
embryonic hindlimb morphogenesis
endocardial cell differentiation
endocardial cushion morphogenesis
endocardium development
endocardium morphogenesis
endoderm development
epithelial to mesenchymal transition
epithelial to mesenchymal transition involved in endocardial cushion formation
forebrain development
foregut morphogenesis
gene expression
glomerular mesangial cell development
growth involved in heart morphogenesis
hair follicle morphogenesis
heart development
heart looping
heart trabecula morphogenesis
humoral immune response
immune response
inflammatory response to antigenic stimulus
interleukin-4 secretion
in utero embryonic development
keratinocyte differentiation
left/right axis specification
liver development
lung development
mesenchymal cell development
mitral valve formation
negative regulation of anoikis
negative regulation of auditory receptor cell differentiation
negative regulation of BMP signaling pathway
negative regulation of calcium ion-dependent exocytosis
negative regulation of canonical Wnt signaling pathway
negative regulation of catalytic activity
negative regulation of cell migration involved in sprouting angiogenesis
negative regulation of cell proliferation
negative regulation of cell-substrate adhesion
negative regulation of endothelial cell chemotaxis
negative regulation of glial cell proliferation
negative regulation of myoblast differentiation
negative regulation of myotube differentiation
negative regulation of neurogenesis
negative regulation of oligodendrocyte differentiation
negative regulation of ossification
negative regulation of osteoblast differentiation
negative regulation of photoreceptor cell differentiation
negative regulation of pro-B cell differentiation
negative regulation of stem cell differentiation
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
neural tube development
neuronal stem cell population maintenance
Notch receptor processing
Notch signaling involved in heart development
Notch signaling pathway
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
oligodendrocyte differentiation
organ regeneration
pericardium morphogenesis
positive regulation of apoptotic process
positive regulation of astrocyte differentiation
positive regulation of BMP signaling pathway
positive regulation of cardiac muscle cell proliferation
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of endothelial cell differentiation
positive regulation of epithelial cell proliferation
positive regulation of epithelial to mesenchymal transition
positive regulation of JAK-STAT cascade
positive regulation of keratinocyte differentiation
positive regulation of neuroblast proliferation
positive regulation of Notch signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
positive regulation of transcription of Notch receptor target
positive regulation of viral genome replication
positive regulation of viral transcription
prostate gland epithelium morphogenesis
pulmonary valve morphogenesis
regulation of epithelial cell proliferation involved in prostate gland development
regulation of extracellular matrix assembly
regulation of somitogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
response to corticosteroid
response to lipopolysaccharide
response to muramyl dipeptide
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
skeletal muscle cell differentiation
somatic stem cell division
spermatogenesis
sprouting angiogenesis
tissue regeneration
transcription initiation from RNA polymerase II promoter
tube formation
vasculogenesis involved in coronary vascular morphogenesis
venous endothelial cell differentiation
ventricular septum morphogenesis
ventricular trabecula myocardium morphogenesis
Gene Ontology Molecular Function:
calcium ion binding
chromatin DNA binding
core promoter binding
enzyme binding
enzyme inhibitor activity
receptor activity
sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription factor binding
transcription factor activity, sequence-specific DNA binding
Gene Ontology Cellular Component:
acrosomal vesicle
adherens junction
apical plasma membrane
cell surface
cytosol
endoplasmic reticulum membrane
extracellular region
Golgi membrane
integral component of membrane
MAML1-RBP-Jkappa- ICN1 complex
nucleoplasm
nucleus
plasma membrane
receptor complex
Keywords:
3D-structure
ANK repeat
Activator
Angiogenesis
Calcium
Cell membrane
Complete proteome
Developmental protein
Differentiation
Direct protein sequencing
Disease mutation
Disulfide bond
EGF-like domain
Glycoprotein
Hydroxylation
Isopeptide bond
Membrane
Metal-binding
Notch signaling pathway
Nucleus
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transcription
Transcription regulation
Transmembrane
Transmembrane helix
Ubl conjugation
Interacts With:
Q8N423; P19838; Q13526; Q06330; Q13573; P98170

Publication

PubMed ID:
15164053 1831692 17573339 10079256 9590294 10713164 11101851 12370315 12050162 18628966 18669648 20616313 22128911 21464124 21147854 21245387 24226769 25547411 12795601 15576031 16011479 16530044 16025100 25132448