Names & Taxonomy
- Uniprot ID:
- P46098
- Entry Name:
- 5HT3A_HUMAN
- Status:
- reviewed
- Protein Names:
- 5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor)
- Gene Names:
- HTR3A 5HT3R HTR3
- Gene Names Primary:
- HTR3A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 478
- Sequence:
- MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Function
- Function:
- This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
- Cross Reference Drug Bank:
- DB00969 DB00543 DB01238 DB01161 DB00604 DB00363 DB00757 DB01049 DB00898 DB00889 DB00408 DB01043 DB00333 DB01233 DB00370 DB00334 DB00904 DB00377 DB00721 DB01224 DB00728 DB06204 DB00726 DB01199 DB09068 DB00246
- Gene Ontology Go:
- axon
cell junction
cytoplasm
integral component of plasma membrane
neuronal cell body
plasma membrane
postsynaptic membrane
G-protein coupled serotonin receptor activity
receptor activity
serotonin binding
serotonin-activated cation-selective channel activity
voltage-gated potassium channel activity
cellular response to growth factor stimulus
digestion
ion transmembrane transport
response to cocaine
response to ethanol
serotonin receptor signaling pathway
synaptic transmission
transmembrane transport
transport - Gene Ontology Biological Process:
- cellular response to growth factor stimulus
digestion
ion transmembrane transport
response to cocaine
response to ethanol
serotonin receptor signaling pathway
synaptic transmission
transmembrane transport
transport - Gene Ontology Molecular Function:
- G-protein coupled serotonin receptor activity
receptor activity
serotonin-activated cation-selective channel activity
serotonin binding
voltage-gated potassium channel activity - Gene Ontology Cellular Component:
- axon
cell junction
cytoplasm
integral component of plasma membrane
neuronal cell body
plasma membrane
postsynaptic membrane - Keywords:
- Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q8WXA8; Q70Z44; A5X5Y0-1; A5X5Y0-3