Names & Taxonomy

Uniprot ID:
P46098
Entry Name:
5HT3A_HUMAN
Status:
reviewed
Protein Names:
5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor)
Gene Names:
HTR3A 5HT3R HTR3
Gene Names Primary:
HTR3A
Organism:
Homo sapiens (Human)

Structure

Length:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Function

Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Cross Reference Drug Bank:
DB00969 DB00543 DB01238 DB01161 DB00604 DB00363 DB00757 DB01049 DB00898 DB00889 DB00408 DB01043 DB00333 DB01233 DB00370 DB00334 DB00904 DB00377 DB00721 DB01224 DB00728 DB06204 DB00726 DB01199 DB09068 DB00246
Gene Ontology Go:
axon
cell junction
cytoplasm
integral component of plasma membrane
neuronal cell body
plasma membrane
postsynaptic membrane
G-protein coupled serotonin receptor activity
receptor activity
serotonin binding
serotonin-activated cation-selective channel activity
voltage-gated potassium channel activity
cellular response to growth factor stimulus
digestion
ion transmembrane transport
response to cocaine
response to ethanol
serotonin receptor signaling pathway
synaptic transmission
transmembrane transport
transport
Gene Ontology Biological Process:
cellular response to growth factor stimulus
digestion
ion transmembrane transport
response to cocaine
response to ethanol
serotonin receptor signaling pathway
synaptic transmission
transmembrane transport
transport
Gene Ontology Molecular Function:
G-protein coupled serotonin receptor activity
receptor activity
serotonin-activated cation-selective channel activity
serotonin binding
voltage-gated potassium channel activity
Gene Ontology Cellular Component:
axon
cell junction
cytoplasm
integral component of plasma membrane
neuronal cell body
plasma membrane
postsynaptic membrane
Keywords:
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q8WXA8; Q70Z44; A5X5Y0-1; A5X5Y0-3

Publication

PubMed ID:
7565620 8848005 9928262 10670426 15028279 14702039 16554811 15489334 9950429 10521471 12867984 15809299 17392525 15293096 16487942