Names & Taxonomy
- Uniprot ID:
- P46059
- Entry Name:
- S15A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 15 member 1 (Intestinal H(+)/peptide cotransporter) (Oligopeptide transporter, small intestine isoform) (Peptide transporter 1)
- Gene Names:
- SLC15A1 PEPT1
- Gene Names Primary:
- SLC15A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 708
- Sequence:
- MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDNLSTAIYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGTPDSLPVHVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTIITPMLRVQQCGIHSKQACYPLAFGVPAALMAVALIVFVLGSGMYKKFKPQGNIMGKVAKCIGFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQIKMVTRVMFLYIPLPMFWALFDQQGSRWTLQATTMSGKIGALEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGFNFTSLKKMAVGMVLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGPMSQTNAFMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQVVKDGLNQKPEKGENGIRFVNTFNELITITMSGKVYANISSYNASTYQFFPSGIKGFTISSTEIPPQCQPNFNTFYLEFGSAYTYIVQRKNDSCPEVKVFEDISANTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAGAGQFSKQWAEYILFAALLLVVCVIFAIMARFYTYINPAEIEAQFDEDEKKNRLEKSNPYFMSGANSQKQM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.
- Cross Reference Drug Bank:
- DB00855 DB01060 DB00415 DB08795 DB00542 DB01053 DB01197 DB00833 DB01140 DB00456 DB00535 DB01413 DB00671 DB00274 DB00493 DB01333 DB00438 DB01415 DB01332 DB01212 DB01112 DB00567 DB00672 DB01340 DB01147 DB01000 DB00485 DB00584 DB01095 DB00492 DB01016 DB01235 DB00722 DB00968 DB00211 DB00691 DB00731 DB00198 DB00713 DB00790 DB00417 DB00881 DB00178 DB01348 DB01124 DB00519 DB00577 DB01610
- Gene Ontology Go:
- brush border
integral component of plasma membrane
membrane
plasma membrane
peptide:proton symporter activity
proton-dependent oligopeptide secondary active transmembrane transporter activity
digestion
ion transport
protein transport
proton transport
transmembrane transport
transport - Gene Ontology Biological Process:
- digestion
ion transport
protein transport
proton transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- peptide:proton symporter activity
proton-dependent oligopeptide secondary active transmembrane transporter activity - Gene Ontology Cellular Component:
- brush border
integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Complete proteome
Glycoprotein
Membrane
Peptide transport
Polymorphism
Protein transport
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport