Names & Taxonomy

Uniprot ID:
P45877
Entry Name:
PPIC_HUMAN
Status:
reviewed
Protein Names:
Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC 5.2.1.8) (Cyclophilin C) (Rotamase C)
Gene Names:
PPIC CYPC
Gene Names Primary:
PPIC
Organism:
Homo sapiens (Human)

Structure

Length:
212
Sequence:
MGPGPRLLLPLVLCVGLGALVFSSGAEGFRKRGPSVTAKVFFDVRIGDKDVGRIVIGLFGKVVPKTVENFVALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVSIYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLTKPTWLDGKHVVFGKVIDGMTVVHSIELQATDGHDRPLTNCSIINSGKIDVKTPFVVEIADW
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic Activity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme Regulation:
ENZYME REGULATION: Cyclosporin A (CsA) inhibits CYPC.
Cross Reference Drug Bank:
DB00172
Gene Ontology Go:
cytoplasm
extracellular exosome
cyclosporin A binding
peptidyl-prolyl cis-trans isomerase activity
protein folding
Gene Ontology Biological Process:
protein folding
Gene Ontology Molecular Function:
cyclosporin A binding
peptidyl-prolyl cis-trans isomerase activity
Gene Ontology Cellular Component:
cytoplasm
extracellular exosome
Keywords:
3D-structure
Complete proteome
Cyclosporin
Cytoplasm
Isomerase
Polymorphism
Reference proteome
Rotamase
Interacts With:
Q8N9N5; O43765; Q9NZ09; Q9UMX0; Q9UMX0-2

Publication

PubMed ID:
8031755 15489334