Names & Taxonomy
- Uniprot ID:
- P45877
- Entry Name:
- PPIC_HUMAN
- Status:
- reviewed
- Protein Names:
- Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC 5.2.1.8) (Cyclophilin C) (Rotamase C)
- Gene Names:
- PPIC CYPC
- Gene Names Primary:
- PPIC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 212
- Sequence:
- MGPGPRLLLPLVLCVGLGALVFSSGAEGFRKRGPSVTAKVFFDVRIGDKDVGRIVIGLFGKVVPKTVENFVALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVSIYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLTKPTWLDGKHVVFGKVIDGMTVVHSIELQATDGHDRPLTNCSIINSGKIDVKTPFVVEIADW
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
- Catalytic Activity:
- Peptidylproline (omega=180) = peptidylproline (omega=0).
- Enzyme Regulation:
- ENZYME REGULATION: Cyclosporin A (CsA) inhibits CYPC.
- Cross Reference Drug Bank:
- DB00172
- Gene Ontology Go:
- cytoplasm
extracellular exosome
cyclosporin A binding
peptidyl-prolyl cis-trans isomerase activity
protein folding - Gene Ontology Biological Process:
- protein folding
- Gene Ontology Molecular Function:
- cyclosporin A binding
peptidyl-prolyl cis-trans isomerase activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome - Keywords:
- 3D-structure
Complete proteome
Cyclosporin
Cytoplasm
Isomerase
Polymorphism
Reference proteome
Rotamase - Interacts With:
- Q8N9N5; O43765; Q9NZ09; Q9UMX0; Q9UMX0-2