Names & Taxonomy

Uniprot ID:
P43220
Entry Name:
GLP1R_HUMAN
Status:
reviewed
Protein Names:
Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R)
Gene Names:
GLP1R
Gene Names Primary:
GLP1R
Organism:
Homo sapiens (Human)

Structure

Length:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Cross Reference Drug Bank:
DB09043 DB09045 DB01276 DB00040 DB06655
Gene Ontology Go:
integral component of membrane
intracellular
plasma membrane
glucagon receptor activity
transmembrane signaling receptor activity
activation of adenylate cyclase activity
cAMP-mediated signaling
cell surface receptor signaling pathway
energy reserve metabolic process
learning or memory
positive regulation of blood pressure
positive regulation of cytosolic calcium ion concentration
regulation of heart contraction
regulation of insulin secretion
response to stress
small molecule metabolic process
Gene Ontology Biological Process:
activation of adenylate cyclase activity
cAMP-mediated signaling
cell surface receptor signaling pathway
energy reserve metabolic process
learning or memory
positive regulation of blood pressure
positive regulation of cytosolic calcium ion concentration
regulation of heart contraction
regulation of insulin secretion
response to stress
small molecule metabolic process
Gene Ontology Molecular Function:
glucagon receptor activity
transmembrane signaling receptor activity
Gene Ontology Cellular Component:
integral component of membrane
intracellular
plasma membrane
Keywords:
3D-structure
ADP-ribosylation
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix
Interacts With:
P60409; P60410; P60411; Q7Z3S9

Publication

PubMed ID:
8405712 8404634 8216285 7517895 7843404 14574404 15489334 9213353 20869417 21901419 22412906 18287102