Names & Taxonomy
- Uniprot ID:
- P43166
- Entry Name:
- CAH7_HUMAN
- Status:
- reviewed
- Protein Names:
- Carbonic anhydrase 7 (EC 4.2.1.1) (Carbonate dehydratase VII) (Carbonic anhydrase VII) (CA-VII)
- Gene Names:
- CA7
- Gene Names Primary:
- CA7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 264
- Sequence:
- MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Reversible hydration of carbon dioxide.
- Catalytic Activity:
- H(2)CO(3) = CO(2) + H(2)O.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), by saccharin and Foscarnet (phosphonoformate trisodium salt).
- Active Site:
- ACT_SITE 66 66 Proton acceptor.
- Cross Reference Drug Bank:
- DB00819 DB01144 DB00703 DB00909
- Gene Ontology Go:
- cytosol
carbonate dehydratase activity
zinc ion binding
bicarbonate transport
mitophagy in response to mitochondrial depolarization
one-carbon metabolic process
positive regulation of cellular pH reduction
positive regulation of defense response to virus by host
positive regulation of synaptic transmission, GABAergic
regulation of chloride transport
small molecule metabolic process
xenophagy - Gene Ontology Biological Process:
- bicarbonate transport
mitophagy in response to mitochondrial depolarization
one-carbon metabolic process
positive regulation of cellular pH reduction
positive regulation of defense response to virus by host
positive regulation of synaptic transmission, GABAergic
regulation of chloride transport
small molecule metabolic process
xenophagy - Gene Ontology Molecular Function:
- carbonate dehydratase activity
zinc ion binding - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Lyase
Metal-binding
Reference proteome
Zinc