Names & Taxonomy
- Uniprot ID:
- P43146
- Entry Name:
- DCC_HUMAN
- Status:
- reviewed
- Protein Names:
- Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC)
- Gene Names:
- DCC IGDCC1
- Gene Names Primary:
- DCC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1447
- Sequence:
- MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQLNAITGSAF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
- Gene Ontology Go:
- axon
cytosol
integral component of membrane
plasma membrane
netrin receptor activity
transmembrane signaling receptor activity
anterior/posterior axon guidance
apoptotic process
axon guidance
axonogenesis
dorsal/ventral axon guidance
extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of collateral sprouting
negative regulation of dendrite development
negative regulation of neuron projection development
neuron migration
programmed cell death
regulation of neuron death
spinal cord ventral commissure morphogenesis - Gene Ontology Biological Process:
- anterior/posterior axon guidance
apoptotic process
axon guidance
axonogenesis
dorsal/ventral axon guidance
extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of collateral sprouting
negative regulation of dendrite development
negative regulation of neuron projection development
neuron migration
programmed cell death
regulation of neuron death
spinal cord ventral commissure morphogenesis - Gene Ontology Molecular Function:
- netrin receptor activity
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- axon
cytosol
integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Apoptosis
Complete proteome
Developmental protein
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Tumor suppressor
Ubl conjugation - Interacts With:
- P56270; Q9HD67; O95631; P46779; P46777; P62266