Names & Taxonomy
- Uniprot ID:
- P43088
- Entry Name:
- PF2R_HUMAN
- Status:
- reviewed
- Protein Names:
- Prostaglandin F2-alpha receptor (PGF receptor) (PGF2-alpha receptor) (Prostanoid FP receptor)
- Gene Names:
- PTGFR
- Gene Names Primary:
- PTGFR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 359
- Sequence:
- MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
- Cross Reference Drug Bank:
- DB00905 DB01160 DB00654 DB08819 DB00287
- Gene Ontology Go:
- cytoplasm
extracellular region
integral component of plasma membrane
plasma membrane
prostaglandin F receptor activity
calcium-mediated signaling using intracellular calcium source
cellular response to prostaglandin D stimulus
G-protein coupled receptor signaling pathway
negative regulation of apoptotic process
parturition
positive regulation of cell proliferation
positive regulation of gene expression
response to estradiol
response to lipopolysaccharide - Gene Ontology Biological Process:
- calcium-mediated signaling using intracellular calcium source
cellular response to prostaglandin D stimulus
G-protein coupled receptor signaling pathway
negative regulation of apoptotic process
parturition
positive regulation of cell proliferation
positive regulation of gene expression
response to estradiol
response to lipopolysaccharide - Gene Ontology Molecular Function:
- prostaglandin F receptor activity
- Gene Ontology Cellular Component:
- cytoplasm
extracellular region
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix