Names & Taxonomy
- Uniprot ID:
- P43026
- Entry Name:
- GDF5_HUMAN
- Status:
- reviewed
- Protein Names:
- Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
- Gene Names:
- GDF5 BMP14 CDMP1
- Gene Names Primary:
- GDF5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 501
- Sequence:
- MRLPKLLTFLLWYLAWLDLEFICTVLGAPDLGQRPQGTRPGLAKAEAKERPPLARNVFRPGGHSYGGGATNANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATARTVTPKGQLPGGKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPASLLDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).
- Cross Reference Drug Bank:
- DB02325
- Gene Ontology Go:
- extracellular region
extracellular space
intracellular
plasma membrane
BMP binding
cytokine activity
growth factor activity
identical protein binding
transforming growth factor beta receptor binding
BMP signaling pathway
cell development
cell-cell signaling
chondroblast differentiation
chondrocyte differentiation
embryonic limb morphogenesis
extracellular matrix organization
forelimb morphogenesis
growth
hindlimb morphogenesis
mitophagy in response to mitochondrial depolarization
negative regulation of chondrocyte differentiation
negative regulation of epithelial cell proliferation
negative regulation of mesenchymal cell apoptotic process
negative regulation of neuron apoptotic process
positive regulation of BMP signaling pathway
positive regulation of chondrocyte differentiation
positive regulation of neuron differentiation
positive regulation of pathway-restricted SMAD protein phosphorylation
regulation of apoptotic process
regulation of MAPK cascade
regulation of multicellular organism growth
SMAD protein import into nucleus
SMAD protein signal transduction
transforming growth factor beta receptor signaling pathway - Gene Ontology Biological Process:
- BMP signaling pathway
cell-cell signaling
cell development
chondroblast differentiation
chondrocyte differentiation
embryonic limb morphogenesis
extracellular matrix organization
forelimb morphogenesis
growth
hindlimb morphogenesis
mitophagy in response to mitochondrial depolarization
negative regulation of chondrocyte differentiation
negative regulation of epithelial cell proliferation
negative regulation of mesenchymal cell apoptotic process
negative regulation of neuron apoptotic process
positive regulation of BMP signaling pathway
positive regulation of chondrocyte differentiation
positive regulation of neuron differentiation
positive regulation of pathway-restricted SMAD protein phosphorylation
regulation of apoptotic process
regulation of MAPK cascade
regulation of multicellular organism growth
SMAD protein import into nucleus
SMAD protein signal transduction
transforming growth factor beta receptor signaling pathway - Gene Ontology Molecular Function:
- BMP binding
cytokine activity
growth factor activity
identical protein binding
transforming growth factor beta receptor binding - Gene Ontology Cellular Component:
- extracellular region
extracellular space
intracellular
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Chondrogenesis
Cleavage on pair of basic residues
Complete proteome
Cytokine
Disease mutation
Disulfide bond
Dwarfism
Glycoprotein
Growth factor
Membrane
Polymorphism
Reference proteome
Secreted
Signal - Interacts With:
- Itself; P36894; O00238; Q13873