Names & Taxonomy
- Uniprot ID:
- P43004
- Entry Name:
- EAA2_HUMAN
- Status:
- reviewed
- Protein Names:
- Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
- Gene Names:
- SLC1A2 EAAT2 GLT1
- Gene Names Primary:
- SLC1A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 574
- Sequence:
- MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYAAHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
- Gene Ontology Go:
- axolemma
cell surface
integral component of membrane
membrane
plasma membrane
presynapse
glutamate:sodium symporter activity
L-glutamate transmembrane transporter activity
sodium:dicarboxylate symporter activity
adult behavior
cellular response to extracellular stimulus
D-aspartate import
glutamate secretion
ion transport
L-glutamate import
multicellular organism aging
multicellular organism growth
neurotransmitter secretion
positive regulation of glucose import
response to amino acid
response to drug
response to wounding
synaptic transmission
telencephalon development
transmembrane transport
visual behavior - Gene Ontology Biological Process:
- adult behavior
cellular response to extracellular stimulus
D-aspartate import
glutamate secretion
ion transport
L-glutamate import
multicellular organism aging
multicellular organism growth
neurotransmitter secretion
positive regulation of glucose import
response to amino acid
response to drug
response to wounding
synaptic transmission
telencephalon development
transmembrane transport
visual behavior - Gene Ontology Molecular Function:
- glutamate:sodium symporter activity
L-glutamate transmembrane transporter activity
sodium:dicarboxylate symporter activity - Gene Ontology Cellular Component:
- axolemma
cell surface
integral component of membrane
membrane
plasma membrane
presynapse - Keywords:
- Alternative splicing
Complete proteome
Glycoprotein
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P10636