Names & Taxonomy

Uniprot ID:
P43004
Entry Name:
EAA2_HUMAN
Status:
reviewed
Protein Names:
Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
Gene Names:
SLC1A2 EAAT2 GLT1
Gene Names Primary:
SLC1A2
Organism:
Homo sapiens (Human)

Structure

Length:
574
Sequence:
MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYAAHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
Gene Ontology Go:
axolemma
cell surface
integral component of membrane
membrane
plasma membrane
presynapse
glutamate:sodium symporter activity
L-glutamate transmembrane transporter activity
sodium:dicarboxylate symporter activity
adult behavior
cellular response to extracellular stimulus
D-aspartate import
glutamate secretion
ion transport
L-glutamate import
multicellular organism aging
multicellular organism growth
neurotransmitter secretion
positive regulation of glucose import
response to amino acid
response to drug
response to wounding
synaptic transmission
telencephalon development
transmembrane transport
visual behavior
Gene Ontology Biological Process:
adult behavior
cellular response to extracellular stimulus
D-aspartate import
glutamate secretion
ion transport
L-glutamate import
multicellular organism aging
multicellular organism growth
neurotransmitter secretion
positive regulation of glucose import
response to amino acid
response to drug
response to wounding
synaptic transmission
telencephalon development
transmembrane transport
visual behavior
Gene Ontology Molecular Function:
glutamate:sodium symporter activity
L-glutamate transmembrane transporter activity
sodium:dicarboxylate symporter activity
Gene Ontology Cellular Component:
axolemma
cell surface
integral component of membrane
membrane
plasma membrane
presynapse
Keywords:
Alternative splicing
Complete proteome
Glycoprotein
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport
Interacts With:
P10636

Publication

PubMed ID:
7521911 8172925 7522567 9463476 12950454 14702039 16554811 15489334 15265858 20688910