Names & Taxonomy
- Uniprot ID:
- P42898
- Entry Name:
- MTHR_HUMAN
- Status:
- reviewed
- Protein Names:
- Methylenetetrahydrofolate reductase (EC 1.5.1.20)
- Gene Names:
- MTHFR
- Gene Names Primary:
- MTHFR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 656
- Sequence:
- MVNEARGNSSLNPCLEGSASSGSESSKDSSRCSTPGLDPERHERLREKMRRRLESGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAGDPGSDKETSSMMIASTAVNYCGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGDPIGDQWEEEEGGFNYAVDLVKHIRSEFGDYFDICVAGYPKGHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDPRRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFEVFVLYLSGEPNRNGHKVTCLPWNDEPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPIVGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYFLVNLVDNDFPLDNCLWQVVEDTLELLNRPTQNARETEAP
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.
- Pathway:
- One-carbon metabolism; tetrahydrofolate interconversion.
- Catalytic Activity:
- 5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Enzyme Regulation:
- ENZYME REGULATION: Allosterically regulated by S-adenosylmethionine.
- Active Site:
- ACT_SITE 63 63 Proton donor/acceptor.
- Cross Reference Drug Bank:
- DB00542 DB00115 DB00544 DB00158 DB00134 DB00170 DB00563 DB00140 DB00116
- Gene Ontology Go:
- cytosol
neuron projection
flavin adenine dinucleotide binding
methylenetetrahydrofolate reductase (NAD(P)H) activity
modified amino acid binding
NADP binding
protein complex binding
blood circulation
cellular amino acid metabolic process
folic acid metabolic process
heterochromatin maintenance
homocysteine metabolic process
methionine metabolic process
regulation of histone methylation
response to drug
response to folic acid
response to hypoxia
response to interleukin-1
response to vitamin B2
S-adenosylmethionine metabolic process
small molecule metabolic process
tetrahydrofolate interconversion
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- blood circulation
cellular amino acid metabolic process
folic acid metabolic process
heterochromatin maintenance
homocysteine metabolic process
methionine metabolic process
regulation of histone methylation
response to drug
response to folic acid
response to hypoxia
response to interleukin-1
response to vitamin B2
S-adenosylmethionine metabolic process
small molecule metabolic process
tetrahydrofolate interconversion
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- flavin adenine dinucleotide binding
methylenetetrahydrofolate reductase (NAD(P)H) activity
modified amino acid binding
NADP binding
protein complex binding - Gene Ontology Cellular Component:
- cytosol
neuron projection - Keywords:
- Allosteric enzyme
Alternative splicing
Complete proteome
Disease mutation
FAD
Flavoprotein
NADP
Oxidoreductase
Polymorphism
Reference proteome