Names & Taxonomy
- Uniprot ID:
- P42892
- Entry Name:
- ECE1_HUMAN
- Status:
- reviewed
- Protein Names:
- Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71)
- Gene Names:
- ECE1
- Gene Names Primary:
- ECE1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 770
- Sequence:
- MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type II membrane protein.
Function
- Function:
- Converts big endothelin-1 to endothelin-1.
- Catalytic Activity:
- Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by phosphoramidon.
- Active Site:
- ACT_SITE 608 608; ACT_SITE 671 671 Proton donor.
- Gene Ontology Go:
- early endosome
endosome
external side of plasma membrane
extracellular exosome
integral component of membrane
intrinsic component of endosome membrane
lysosomal membrane
membrane
perinuclear region of cytoplasm
plasma membrane
vesicle
Weibel-Palade body
endopeptidase activity
metal ion binding
metalloendopeptidase activity
peptide hormone binding
protein homodimerization activity
apoptotic process
bradykinin catabolic process
calcitonin catabolic process
ear development
embryonic digit morphogenesis
endothelin maturation
heart development
hormone catabolic process
peptide hormone processing
pharyngeal system development
positive regulation of cAMP biosynthetic process
positive regulation of cardiac muscle hypertrophy
positive regulation of G-protein coupled receptor protein signaling pathway
positive regulation of receptor recycling
protein processing
regulation of ERK1 and ERK2 cascade
regulation of systemic arterial blood pressure by endothelin
regulation of vasoconstriction
regulation of vasodilation
response to cadmium ion
response to drug
response to hypoxia
response to muscle stretch
substance P catabolic process - Gene Ontology Biological Process:
- apoptotic process
bradykinin catabolic process
calcitonin catabolic process
ear development
embryonic digit morphogenesis
endothelin maturation
heart development
hormone catabolic process
peptide hormone processing
pharyngeal system development
positive regulation of cAMP biosynthetic process
positive regulation of cardiac muscle hypertrophy
positive regulation of G-protein coupled receptor protein signaling pathway
positive regulation of receptor recycling
protein processing
regulation of ERK1 and ERK2 cascade
regulation of systemic arterial blood pressure by endothelin
regulation of vasoconstriction
regulation of vasodilation
response to cadmium ion
response to drug
response to hypoxia
response to muscle stretch
substance P catabolic process - Gene Ontology Molecular Function:
- endopeptidase activity
metal ion binding
metalloendopeptidase activity
peptide hormone binding
protein homodimerization activity - Gene Ontology Cellular Component:
- early endosome
endosome
external side of plasma membrane
extracellular exosome
integral component of membrane
intrinsic component of endosome membrane
lysosomal membrane
membrane
perinuclear region of cytoplasm
plasma membrane
vesicle
Weibel-Palade body - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Hirschsprung disease
Hydrolase
Membrane
Metal-binding
Metalloprotease
Phosphoprotein
Polymorphism
Protease
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix
Zinc - Interacts With:
- P49760; P60370