Names & Taxonomy
- Uniprot ID:
- P42768
- Entry Name:
- WASP_HUMAN
- Status:
- reviewed
- Protein Names:
- Wiskott-Aldrich syndrome protein (WASp)
- Gene Names:
- WAS IMD2
- Gene Names Primary:
- WAS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 502
- Sequence:
- MSGGPMGGRPGGRGAPAVQQNIPSTLLQDHENQRLFEMLGRKCLTLATAVVQLYLALPPGAEHWTKEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLHPGGDQGGPPVGPLSLGLATVDIQNPDITSSRYRGLPAPGPSPADKKRSGKKKISKADIGAPSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQEMRRQEPLPPPPPPSRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPPPPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPALVPAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSRAIHSSDEGEDQAGDEDEDDEWDD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton.
Function
- Function:
- Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria.
- Gene Ontology Go:
- actin cytoskeleton
cell-cell junction
cytosol
extracellular exosome
vesicle membrane
GTPase regulator activity
identical protein binding
phospholipase binding
protein kinase binding
SH3 domain binding
actin filament polymerization
actin filament-based movement
actin polymerization or depolymerization
blood coagulation
defense response
endosomal transport
epidermis development
Fc-gamma receptor signaling pathway involved in phagocytosis
immune response
innate immune response
negative regulation of cell motility
positive regulation of Arp2/3 complex-mediated actin nucleation
protein complex assembly
regulation of catalytic activity
regulation of T cell antigen processing and presentation
small GTPase mediated signal transduction
T cell activation
T cell receptor signaling pathway - Gene Ontology Biological Process:
- actin filament-based movement
actin filament polymerization
actin polymerization or depolymerization
blood coagulation
defense response
endosomal transport
epidermis development
Fc-gamma receptor signaling pathway involved in phagocytosis
immune response
innate immune response
negative regulation of cell motility
positive regulation of Arp2/3 complex-mediated actin nucleation
protein complex assembly
regulation of catalytic activity
regulation of T cell antigen processing and presentation
small GTPase mediated signal transduction
T cell activation
T cell receptor signaling pathway - Gene Ontology Molecular Function:
- GTPase regulator activity
identical protein binding
phospholipase binding
protein kinase binding
SH3 domain binding - Gene Ontology Cellular Component:
- actin cytoskeleton
cell-cell junction
cytosol
extracellular exosome
vesicle membrane - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Phosphoprotein
Reference proteome
Repeat - Interacts With:
- Itself; Q9P2A4; Q92624; Q06187; P60953; Q14247; P08631; P08103; O43639; Q8WV41; O94875; O43516
Publication
- PubMed ID:
- 8069912 7753869 10066431 15772651 15489334 12665801 8643625 9405671 12235133 12769847 14707117 15592455 18088087 19690332 21269460 24275569 25944712 10360578 10724160 15235593 16275905 17329259 18650809 8528198 8528199 7795648 8682510 9126958 9098856 9683546 9713366 9445409 11167787 11242115 10447259 11877312 11793485 24115682