Names & Taxonomy

Uniprot ID:
P42685
Entry Name:
FRK_HUMAN
Status:
reviewed
Protein Names:
Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5)
Gene Names:
FRK PTK5 RAK
Gene Names Primary:
FRK
Organism:
Homo sapiens (Human)

Structure

Length:
505
Sequence:
MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Catalytic Activity:
ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
Active Site:
ACT_SITE 354 354 Proton acceptor.
Cross Reference Drug Bank:
DB08896
Gene Ontology Go:
cytoplasm
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane
intracellular
intracellular membrane-bounded organelle
nucleus
ATP binding
non-membrane spanning protein tyrosine kinase activity
receptor binding
cell differentiation
innate immune response
negative regulation of cell proliferation
negative regulation of transcription from RNA polymerase II promoter
peptidyl-tyrosine autophosphorylation
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
Gene Ontology Biological Process:
cell differentiation
innate immune response
negative regulation of cell proliferation
negative regulation of transcription from RNA polymerase II promoter
peptidyl-tyrosine autophosphorylation
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
Gene Ontology Molecular Function:
ATP binding
non-membrane spanning protein tyrosine kinase activity
receptor binding
Gene Ontology Cellular Component:
cytoplasm
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane
intracellular
intracellular membrane-bounded organelle
nucleus
Keywords:
ATP-binding
Alternative splicing
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
SH2 domain
SH3 domain
Transferase
Tumor suppressor
Tyrosine-protein kinase
Interacts With:
Q12982; P60484; P06400; Q15427

Publication

PubMed ID:
7696183 7510261 14702039 14574404 15489334 8099900 7664264 18691976 19345329 19652529 24275569 17344846