Names & Taxonomy
- Uniprot ID:
- P42685
- Entry Name:
- FRK_HUMAN
- Status:
- reviewed
- Protein Names:
- Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5)
- Gene Names:
- FRK PTK5 RAK
- Gene Names Primary:
- FRK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 505
- Sequence:
- MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 354 354 Proton acceptor.
- Cross Reference Drug Bank:
- DB08896
- Gene Ontology Go:
- cytoplasm
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane
intracellular
intracellular membrane-bounded organelle
nucleus
ATP binding
non-membrane spanning protein tyrosine kinase activity
receptor binding
cell differentiation
innate immune response
negative regulation of cell proliferation
negative regulation of transcription from RNA polymerase II promoter
peptidyl-tyrosine autophosphorylation
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Biological Process:
- cell differentiation
innate immune response
negative regulation of cell proliferation
negative regulation of transcription from RNA polymerase II promoter
peptidyl-tyrosine autophosphorylation
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Molecular Function:
- ATP binding
non-membrane spanning protein tyrosine kinase activity
receptor binding - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane
intracellular
intracellular membrane-bounded organelle
nucleus - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
SH2 domain
SH3 domain
Transferase
Tumor suppressor
Tyrosine-protein kinase - Interacts With:
- Q12982; P60484; P06400; Q15427