Names & Taxonomy

Uniprot ID:
P42680
Entry Name:
TEC_HUMAN
Status:
reviewed
Protein Names:
Tyrosine-protein kinase Tec (EC 2.7.10.2)
Gene Names:
TEC PSCTK4
Gene Names Primary:
TEC
Organism:
Homo sapiens (Human)

Structure

Length:
631
Sequence:
MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIKCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEETFGR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity).

Function

Function:
Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation.
Catalytic Activity:
ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Enzyme Regulation:
ENZYME REGULATION: Activated by tyrosine phosphorylation by a wide range of cytokine stimulations. When T-cells or B-cells receptors are activated, a series of phosphorylation leads to the recruitment of TEC to the cell membrane, where it is phosphorylated at Tyr-519. Also activated in response to SCF. Integrin engagement induces tyrosine phosphorylation of TEC in platelets. STAP1 participates in a positive feedback loop by increasing the activity of TEC. SOCS1 is an inhibitor of TEC kinase activity.
Active Site:
ACT_SITE 489 489 Proton acceptor.
Gene Ontology Go:
cytoskeleton
cytosol
extrinsic component of cytoplasmic side of plasma membrane
ATP binding
metal ion binding
non-membrane spanning protein tyrosine kinase activity
phospholipid binding
adaptive immune response
B cell receptor signaling pathway
cell differentiation
Fc-epsilon receptor signaling pathway
innate immune response
integrin-mediated signaling pathway
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
peptidyl-tyrosine phosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
protein phosphorylation
regulation of cell proliferation
regulation of platelet activation
tissue regeneration
transmembrane receptor protein tyrosine kinase signaling pathway
Gene Ontology Biological Process:
adaptive immune response
B cell receptor signaling pathway
cell differentiation
Fc-epsilon receptor signaling pathway
innate immune response
integrin-mediated signaling pathway
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
peptidyl-tyrosine phosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
protein phosphorylation
regulation of cell proliferation
regulation of platelet activation
tissue regeneration
transmembrane receptor protein tyrosine kinase signaling pathway
Gene Ontology Molecular Function:
ATP binding
metal ion binding
non-membrane spanning protein tyrosine kinase activity
phospholipid binding
Gene Ontology Cellular Component:
cytoskeleton
cytosol
extrinsic component of cytoplasmic side of plasma membrane
Keywords:
3D-structure
ATP-binding
Adaptive immunity
Cell membrane
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Immunity
Kinase
Lipid-binding
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
SH2 domain
SH3 domain
Transferase
Tyrosine-protein kinase
Zinc
Zinc-finger
Interacts With:
Q13480; P08581

Publication

PubMed ID:
7934162 15489334 12573241 7526158 9299487 9341160 9753425 9652744 10518561 15492005 19807924 19369195 19690332 19883687 20230531 17344846