Names & Taxonomy
- Uniprot ID:
- P41968
- Entry Name:
- MC3R_HUMAN
- Status:
- reviewed
- Protein Names:
- Melanocortin receptor 3 (MC3-R)
- Gene Names:
- MC3R
- Gene Names Primary:
- MC3R
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 323
- Sequence:
- MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
melanocortin receptor activity
melanocyte-stimulating hormone receptor activity
neuropeptide binding
peptide hormone binding
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
circadian regulation of gene expression
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
homoiothermy
locomotor rhythm
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cAMP biosynthetic process
regulation of blood pressure
regulation of feeding behavior
regulation of heart rate
sodium ion homeostasis - Gene Ontology Biological Process:
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
circadian regulation of gene expression
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
homoiothermy
locomotor rhythm
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cAMP biosynthetic process
regulation of blood pressure
regulation of feeding behavior
regulation of heart rate
sodium ion homeostasis - Gene Ontology Molecular Function:
- melanocortin receptor activity
melanocyte-stimulating hormone receptor activity
neuropeptide binding
peptide hormone binding - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Biological rhythms
Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix