Names & Taxonomy

Uniprot ID:
P41595
Entry Name:
5HT2B_HUMAN
Status:
reviewed
Protein Names:
5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (Serotonin receptor 2B)
Gene Names:
HTR2B
Gene Names Primary:
HTR2B
Organism:
Homo sapiens (Human)

Structure

Length:
481
Sequence:
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome

Function

Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.
Cross Reference Drug Bank:
DB00543 DB00714 DB06216 DB01200 DB00248 DB06016 DB00477 DB01239 DB01242 DB00320 DB01142 DB00216 DB01049 DB01221 DB00589 DB00247 DB06148 DB00805 DB00370 DB00334 DB01186 DB00413 DB00268 DB00508 DB01392
Gene Ontology Go:
cell junction
cytoplasm
dendrite
integral component of plasma membrane
neuronal cell body
plasma membrane
synapse
drug binding
G-protein alpha-subunit binding
G-protein coupled serotonin receptor activity
GTPase activator activity
serotonin binding
activation of phospholipase C activity
behavior
calcium-mediated signaling
cardiac muscle hypertrophy
cellular calcium ion homeostasis
cellular response to amine stimulus
cellular response to serotonin
cellular response to temperature stimulus
cGMP biosynthetic process
embryonic morphogenesis
ERK1 and ERK2 cascade
G-protein coupled receptor internalization
G-protein coupled receptor signaling pathway
heart morphogenesis
hepatic stellate cell activation
inositol phosphate metabolic process
intestine smooth muscle contraction
negative regulation of apoptotic process
negative regulation of autophagy
negative regulation of cell death
neural crest cell differentiation
neural crest cell migration
phosphatidylinositol 3-kinase signaling
phosphorylation
positive regulation of cell division
positive regulation of cell proliferation
positive regulation of cytokine production
positive regulation of cytokine secretion
positive regulation of endothelial cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAP kinase activity
positive regulation of nitric-oxide synthase activity
positive regulation of phosphatidylinositol biosynthetic process
protein kinase C signaling
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of behavior
release of sequestered calcium ion into cytosol
response to drug
serotonin receptor signaling pathway
vasoconstriction
Gene Ontology Biological Process:
activation of phospholipase C activity
behavior
calcium-mediated signaling
cardiac muscle hypertrophy
cellular calcium ion homeostasis
cellular response to amine stimulus
cellular response to serotonin
cellular response to temperature stimulus
cGMP biosynthetic process
embryonic morphogenesis
ERK1 and ERK2 cascade
G-protein coupled receptor internalization
G-protein coupled receptor signaling pathway
heart morphogenesis
hepatic stellate cell activation
inositol phosphate metabolic process
intestine smooth muscle contraction
negative regulation of apoptotic process
negative regulation of autophagy
negative regulation of cell death
neural crest cell differentiation
neural crest cell migration
phosphatidylinositol 3-kinase signaling
phosphorylation
positive regulation of cell division
positive regulation of cell proliferation
positive regulation of cytokine production
positive regulation of cytokine secretion
positive regulation of endothelial cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAP kinase activity
positive regulation of nitric-oxide synthase activity
positive regulation of phosphatidylinositol biosynthetic process
protein kinase C-activating G-protein coupled receptor signaling pathway
protein kinase C signaling
regulation of behavior
release of sequestered calcium ion into cytosol
response to drug
serotonin receptor signaling pathway
vasoconstriction
Gene Ontology Molecular Function:
drug binding
G-protein alpha-subunit binding
G-protein coupled serotonin receptor activity
GTPase activator activity
serotonin binding
Gene Ontology Cellular Component:
cell junction
cytoplasm
dendrite
integral component of plasma membrane
neuronal cell body
plasma membrane
synapse
Keywords:
3D-structure
Behavior
Cell junction
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Synapse
Synaptosome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
8143856 7926008 8078486 10722792 14702039 15815621 15489334 8882600 11150294 12970106 18476671 18703043 21179162 20945968 23519210 23519215