Names & Taxonomy
- Uniprot ID:
- P41250
- Entry Name:
- SYG_HUMAN
- Status:
- reviewed
- Protein Names:
- Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (AP-4-A synthetase) (Glycyl-tRNA synthetase) (GlyRS)
- Gene Names:
- GARS
- Gene Names Primary:
- GARS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 739
- Sequence:
- MPSPRPVLLRGARAALLLLLPPRLLARPSLLLRRSLSAASCPPISLPAAASRSSMDGAGAEEVLAPLRLAVRQQGDLVRKLKEDKAPQVDVDKAVAELKARKRVLEAKELALQPKDDIVDRAKMEDTLKRRFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQHFIQEEQILEIDCTMLTPEPVLKTSGHVDKFADFMVKDVKNGECFRADHLLKAHLQKLMSDKKCSVEKKSEMESVLAQLDNYGQQELADLFVNYNVKSPITGNDLSPPVSFNLMFKTFIGPGGNMPGYLRPETAQGIFLNFKRLLEFNQGKLPFAAAQIGNSFRNEISPRSGLIRVREFTMAEIEHFVDPSEKDHPKFQNVADLHLYLYSAKAQVSGQSARKMRLGDAVEQGVINNTVLGYFIGRIYLYLTKVGISPDKLRFRQHMENEMAHYACDCWDAESKTSYGWIEIVGCADRSCYDLSCHARATKVPLVAEKPLKEPKTVNVVQFEPSKGAIGKAYKKDAKLVMEYLAICDECYITEMEMLLNEKGEFTIETEGKTFQLTKDMINVKRFQKTLYVEEVVPNVIEPSFGLGRIMYTVFEHTFHVREGDEQRTFFSFPAVVAPFKCSVLPLSQNQEFMPFVKELSEALTRHGVSHKVDDSSGSIGRRYARTDEIGVAFGVTIDFDTVNKTPHTATLRDRDSMRQIRAEISELPSIVQDLANGNITWADVEARYPLFEGQETGKKETIEE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs.
- Catalytic Activity:
- ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.3 uM for tRNA(Gly(GCC))
- Cross Reference Drug Bank:
- DB00145
- Gene Ontology Go:
- axon
cytoplasm
cytosol
extracellular exosome
mitochondrial matrix
nucleoplasm
secretory granule
ATP binding
glycine-tRNA ligase activity
protein dimerization activity
diadenosine tetraphosphate biosynthetic process
gene expression
glycyl-tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- diadenosine tetraphosphate biosynthetic process
gene expression
glycyl-tRNA aminoacylation
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- ATP binding
glycine-tRNA ligase activity
protein dimerization activity - Gene Ontology Cellular Component:
- axon
cytoplasm
cytosol
extracellular exosome
mitochondrial matrix
nucleoplasm
secretory granule - Keywords:
- 3D-structure
ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Cell projection
Charcot-Marie-Tooth disease
Complete proteome
Cytoplasm
Disease mutation
Ligase
Mitochondrion
Neurodegeneration
Neuropathy
Nucleotide-binding
Phosphoprotein
Protein biosynthesis
Reference proteome