Names & Taxonomy

Uniprot ID:
P41231
Entry Name:
P2RY2_HUMAN
Status:
reviewed
Protein Names:
P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (P2U receptor 1) (Purinergic receptor)
Gene Names:
P2RY2 P2RU1
Gene Names Primary:
P2RY2
Organism:
Homo sapiens (Human)

Structure

Length:
377
Sequence:
MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
Cross Reference Drug Bank:
DB04786
Gene Ontology Go:
apical plasma membrane
basolateral plasma membrane
cytosol
early endosome
integral component of plasma membrane
lysosome
mitochondrion
plasma membrane
ATP binding
G-protein coupled purinergic nucleotide receptor activity
receptor activity
UTP-activated nucleotide receptor activity
aging
cellular ion homeostasis
cellular response to interleukin-1
cellular response to lipopolysaccharide
cellular response to purine-containing compound
in utero embryonic development
negative regulation of ossification
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of chemokine production
positive regulation of cytosolic calcium ion concentration
positive regulation of mucus secretion
positive regulation of neuron projection development
positive regulation of penile erection
positive regulation of prostaglandin secretion
positive regulation of smooth muscle cell migration
regulation of vasodilation
response to growth factor
sensory perception of pain
wound healing
Gene Ontology Biological Process:
aging
cellular ion homeostasis
cellular response to interleukin-1
cellular response to lipopolysaccharide
cellular response to purine-containing compound
in utero embryonic development
negative regulation of ossification
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of chemokine production
positive regulation of cytosolic calcium ion concentration
positive regulation of mucus secretion
positive regulation of neuron projection development
positive regulation of penile erection
positive regulation of prostaglandin secretion
positive regulation of smooth muscle cell migration
regulation of vasodilation
response to growth factor
sensory perception of pain
wound healing
Gene Ontology Molecular Function:
ATP binding
G-protein coupled purinergic nucleotide receptor activity
receptor activity
UTP-activated nucleotide receptor activity
Gene Ontology Cellular Component:
apical plasma membrane
basolateral plasma membrane
cytosol
early endosome
integral component of plasma membrane
lysosome
mitochondrion
plasma membrane
Keywords:
3D-structure
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
8159738 7809171 14702039 16554811 15489334