Names & Taxonomy
- Uniprot ID:
- P41180
- Entry Name:
- CASR_HUMAN
- Status:
- reviewed
- Protein Names:
- Extracellular calcium-sensing receptor (CaSR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1)
- Gene Names:
- CASR GPRC2A PCAR1
- Gene Names Primary:
- CASR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1078
- Sequence:
- MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHQPLLPLQCGETDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
- Cross Reference Drug Bank:
- DB01012
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
G-protein coupled receptor activity
phosphatidylinositol phospholipase C activity
anatomical structure morphogenesis
calcium ion import
cellular calcium ion homeostasis
chemosensory behavior
detection of calcium ion
G-protein coupled receptor signaling pathway
ossification - Gene Ontology Biological Process:
- anatomical structure morphogenesis
calcium ion import
cellular calcium ion homeostasis
chemosensory behavior
detection of calcium ion
G-protein coupled receptor signaling pathway
ossification - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
phosphatidylinositol phospholipase C activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Epilepsy
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix
Ubl conjugation - Interacts With:
- Q15363
Publication
- PubMed ID:
- 7759551 7677761 8756555 15489334 7673400 8613532 16513638 20861236 7916660 7874174 7726161 8675635 8698326 8733126 8813042 9298824 9253358 9253359 9661634 10468915 9920108 10487661 10023897 10843194 11762699 11161843 12050233 12107202 12241879 12574188 12915654 15531522 15579740 14985373 15551332 15879434 15572418 16598859 16608894 17473068 17698911 18756473 20846291 21643651