Names & Taxonomy

Uniprot ID:
P41180
Entry Name:
CASR_HUMAN
Status:
reviewed
Protein Names:
Extracellular calcium-sensing receptor (CaSR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1)
Gene Names:
CASR GPRC2A PCAR1
Gene Names Primary:
CASR
Organism:
Homo sapiens (Human)

Structure

Length:
1078
Sequence:
MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHQPLLPLQCGETDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Cross Reference Drug Bank:
DB01012
Gene Ontology Go:
integral component of plasma membrane
plasma membrane
G-protein coupled receptor activity
phosphatidylinositol phospholipase C activity
anatomical structure morphogenesis
calcium ion import
cellular calcium ion homeostasis
chemosensory behavior
detection of calcium ion
G-protein coupled receptor signaling pathway
ossification
Gene Ontology Biological Process:
anatomical structure morphogenesis
calcium ion import
cellular calcium ion homeostasis
chemosensory behavior
detection of calcium ion
G-protein coupled receptor signaling pathway
ossification
Gene Ontology Molecular Function:
G-protein coupled receptor activity
phosphatidylinositol phospholipase C activity
Gene Ontology Cellular Component:
integral component of plasma membrane
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Epilepsy
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix
Ubl conjugation
Interacts With:
Q15363

Publication

PubMed ID:
7759551 7677761 8756555 15489334 7673400 8613532 16513638 20861236 7916660 7874174 7726161 8675635 8698326 8733126 8813042 9298824 9253358 9253359 9661634 10468915 9920108 10487661 10023897 10843194 11762699 11161843 12050233 12107202 12241879 12574188 12915654 15531522 15579740 14985373 15551332 15879434 15572418 16598859 16608894 17473068 17698911 18756473 20846291 21643651