Names & Taxonomy
- Uniprot ID:
- P40394
- Entry Name:
- ADH7_HUMAN
- Status:
- reviewed
- Protein Names:
- Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Gastric alcohol dehydrogenase) (Retinol dehydrogenase)
- Gene Names:
- ADH7
- Gene Names Primary:
- ADH7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 386
- Sequence:
- MFAEIQIQDKDRMGTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSKFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFELLNSGQSIRTVLTF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.
- Catalytic Activity:
- An alcohol + NAD(+) = an aldehyde or ketone + NADH.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 2 Zn(2+) ions per subunit.;
- Cross Reference Drug Bank:
- DB00898
- Gene Ontology Go:
- cytosol
extracellular region
alcohol dehydrogenase (NAD) activity
alcohol dehydrogenase activity, zinc-dependent
aldehyde oxidase activity
ethanol binding
receptor antagonist activity
retinol binding
retinol dehydrogenase activity
zinc ion binding
ethanol catabolic process
ethanol oxidation
extracellular negative regulation of signal transduction
fatty acid omega-oxidation
oxidation-reduction process
response to bacterium
response to ethanol
retinoic acid metabolic process
retinoid metabolic process
retinol metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- ethanol catabolic process
ethanol oxidation
extracellular negative regulation of signal transduction
fatty acid omega-oxidation
oxidation-reduction process
response to bacterium
response to ethanol
retinoic acid metabolic process
retinoid metabolic process
retinol metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- alcohol dehydrogenase (NAD) activity
alcohol dehydrogenase activity, zinc-dependent
aldehyde oxidase activity
ethanol binding
receptor antagonist activity
retinol binding
retinol dehydrogenase activity
zinc ion binding - Gene Ontology Cellular Component:
- cytosol
extracellular region - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Metal-binding
NAD
Oxidoreductase
Polymorphism
Reference proteome
Zinc