Names & Taxonomy
- Uniprot ID:
- P36969
- Entry Name:
- GPX4_HUMAN
- Status:
- reviewed
- Protein Names:
- Phospholipid hydroperoxide glutathione peroxidase, mitochondrial (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4)
- Gene Names:
- GPX4
- Gene Names Primary:
- GPX4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 197
- Sequence:
- MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform Mitochondrial: Mitochondrion.; Isoform Cytoplasmic: Cytoplasm.
Function
- Function:
- Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.
- Catalytic Activity:
- 2 glutathione + a hydroperoxy-fatty-acyl- = glutathione disulfide + a hydroxy-fatty-acyl- + H(2)O.
- Active Site:
- ACT_SITE 73 73
- Cross Reference Drug Bank:
- DB00143
- Gene Ontology Go:
- cytosol
extracellular exosome
mitochondrion
nucleus
glutathione peroxidase activity
phospholipid-hydroperoxide glutathione peroxidase activity
arachidonic acid metabolic process
cellular oxidant detoxification
lipoxygenase pathway
multicellular organism development
oxidation-reduction process
phospholipid metabolic process
response to oxidative stress
small molecule metabolic process - Gene Ontology Biological Process:
- arachidonic acid metabolic process
cellular oxidant detoxification
lipoxygenase pathway
multicellular organism development
oxidation-reduction process
phospholipid metabolic process
response to oxidative stress
small molecule metabolic process - Gene Ontology Molecular Function:
- glutathione peroxidase activity
phospholipid-hydroperoxide glutathione peroxidase activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
mitochondrion
nucleus - Keywords:
- 3D-structure
Alternative initiation
Complete proteome
Cytoplasm
Developmental protein
Dwarfism
Mitochondrion
Oxidoreductase
Peroxidase
Polymorphism
Reference proteome
Selenocysteine
Transit peptide