Names & Taxonomy

Uniprot ID:
P36969
Entry Name:
GPX4_HUMAN
Status:
reviewed
Protein Names:
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4)
Gene Names:
GPX4
Gene Names Primary:
GPX4
Organism:
Homo sapiens (Human)

Structure

Length:
197
Sequence:
MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform Mitochondrial: Mitochondrion.; Isoform Cytoplasmic: Cytoplasm.

Function

Function:
Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.
Catalytic Activity:
2 glutathione + a hydroperoxy-fatty-acyl- = glutathione disulfide + a hydroxy-fatty-acyl- + H(2)O.
Active Site:
ACT_SITE 73 73
Cross Reference Drug Bank:
DB00143
Gene Ontology Go:
cytosol
extracellular exosome
mitochondrion
nucleus
glutathione peroxidase activity
phospholipid-hydroperoxide glutathione peroxidase activity
arachidonic acid metabolic process
cellular oxidant detoxification
lipoxygenase pathway
multicellular organism development
oxidation-reduction process
phospholipid metabolic process
response to oxidative stress
small molecule metabolic process
Gene Ontology Biological Process:
arachidonic acid metabolic process
cellular oxidant detoxification
lipoxygenase pathway
multicellular organism development
oxidation-reduction process
phospholipid metabolic process
response to oxidative stress
small molecule metabolic process
Gene Ontology Molecular Function:
glutathione peroxidase activity
phospholipid-hydroperoxide glutathione peroxidase activity
Gene Ontology Cellular Component:
cytosol
extracellular exosome
mitochondrion
nucleus
Keywords:
3D-structure
Alternative initiation
Complete proteome
Cytoplasm
Developmental protein
Dwarfism
Mitochondrion
Oxidoreductase
Peroxidase
Polymorphism
Reference proteome
Selenocysteine
Transit peptide

Publication

PubMed ID:
8039723 9705830 15057824 15489334 21269460 24275569 25944712 17630701 12606444 24706940