Names & Taxonomy

Uniprot ID:
P36959
Entry Name:
GMPR1_HUMAN
Status:
reviewed
Protein Names:
GMP reductase 1 (GMPR 1) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1)
Gene Names:
GMPR GMPR1
Gene Names Primary:
GMPR
Organism:
Homo sapiens (Human)

Structure

Length:
345
Sequence:
MPRIDADLKLDFKDVLLRPKRSSLKSRAEVDLERTFTFRNSKQTYSGIPIIVANMDTVGTFEMAAVMSQHSMFTAIHKHYSLDDWKLFATNHPECLQNVAVSSGSGQNDLEKMTSILEAVPQVKFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVMLGGMFSGHTECAGEVFERNGRKLKLFYGMSSDTAMNKHAGGVAEYRASEGKTVEVPYKGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVTQQHNTVFS
Proteomes:
UP000005640

Function

Function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Catalytic Activity:
Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH.
Active Site:
ACT_SITE 186 186 Thioimidate intermediate.
Gene Ontology Go:
cytosol
GMP reductase complex
GMP reductase activity
metal ion binding
nucleobase-containing small molecule metabolic process
purine nucleobase metabolic process
purine nucleotide metabolic process
purine-containing compound salvage
response to cold
small molecule metabolic process
Gene Ontology Biological Process:
nucleobase-containing small molecule metabolic process
purine-containing compound salvage
purine nucleobase metabolic process
purine nucleotide metabolic process
response to cold
small molecule metabolic process
Gene Ontology Molecular Function:
GMP reductase activity
metal ion binding
Gene Ontology Cellular Component:
cytosol
GMP reductase complex
Keywords:
3D-structure
Complete proteome
Metal-binding
NADP
Oxidoreductase
Polymorphism
Potassium
Purine metabolism
Reference proteome

Publication

PubMed ID:
2758468 1661705 14574404 15489334 2570640 1694726 21269460 1757097