Names & Taxonomy
- Uniprot ID:
- P36959
- Entry Name:
- GMPR1_HUMAN
- Status:
- reviewed
- Protein Names:
- GMP reductase 1 (GMPR 1) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1)
- Gene Names:
- GMPR GMPR1
- Gene Names Primary:
- GMPR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 345
- Sequence:
- MPRIDADLKLDFKDVLLRPKRSSLKSRAEVDLERTFTFRNSKQTYSGIPIIVANMDTVGTFEMAAVMSQHSMFTAIHKHYSLDDWKLFATNHPECLQNVAVSSGSGQNDLEKMTSILEAVPQVKFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVMLGGMFSGHTECAGEVFERNGRKLKLFYGMSSDTAMNKHAGGVAEYRASEGKTVEVPYKGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVTQQHNTVFS
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
- Catalytic Activity:
- Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH.
- Active Site:
- ACT_SITE 186 186 Thioimidate intermediate.
- Gene Ontology Go:
- cytosol
GMP reductase complex
GMP reductase activity
metal ion binding
nucleobase-containing small molecule metabolic process
purine nucleobase metabolic process
purine nucleotide metabolic process
purine-containing compound salvage
response to cold
small molecule metabolic process - Gene Ontology Biological Process:
- nucleobase-containing small molecule metabolic process
purine-containing compound salvage
purine nucleobase metabolic process
purine nucleotide metabolic process
response to cold
small molecule metabolic process - Gene Ontology Molecular Function:
- GMP reductase activity
metal ion binding - Gene Ontology Cellular Component:
- cytosol
GMP reductase complex - Keywords:
- 3D-structure
Complete proteome
Metal-binding
NADP
Oxidoreductase
Polymorphism
Potassium
Purine metabolism
Reference proteome