Names & Taxonomy
- Uniprot ID:
- P36544
- Entry Name:
- ACHA7_HUMAN
- Status:
- reviewed
- Protein Names:
- Neuronal acetylcholine receptor subunit alpha-7
- Gene Names:
- CHRNA7 NACHRA7
- Gene Names Primary:
- CHRNA7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 502
- Sequence:
- MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Function
- Function:
- After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
- Cross Reference Drug Bank:
- DB01351 DB01352 DB00237 DB00241 DB01353 DB09028 DB00514 DB00898 DB00674 DB01354 DB01355 DB00849 DB00184 DB00312 DB01174 DB00794 DB00418 DB00306 DB00599 DB01273
- Gene Ontology Go:
- acetylcholine-gated channel complex
cell junction
integral component of membrane
plasma membrane
postsynaptic membrane
acetylcholine binding
acetylcholine receptor activity
acetylcholine-activated cation-selective channel activity
acetylcholine-gated cation channel activity
beta-amyloid binding
chloride channel regulator activity
protein homodimerization activity
toxic substance binding
activation of MAPK activity
calcium ion transport
cation transmembrane transport
cellular calcium ion homeostasis
chemical synaptic transmission, postsynaptic
cognition
ion transmembrane transport
ion transport
memory
negative regulation of tumor necrosis factor production
positive regulation of angiogenesis
positive regulation of cell proliferation
response to hypoxia
response to nicotine
signal transduction
synaptic transmission
synaptic transmission, cholinergic - Gene Ontology Biological Process:
- activation of MAPK activity
calcium ion transport
cation transmembrane transport
cellular calcium ion homeostasis
chemical synaptic transmission, postsynaptic
cognition
ion transmembrane transport
ion transport
memory
negative regulation of tumor necrosis factor production
positive regulation of angiogenesis
positive regulation of cell proliferation
response to hypoxia
response to nicotine
signal transduction
synaptic transmission
synaptic transmission, cholinergic - Gene Ontology Molecular Function:
- acetylcholine-activated cation-selective channel activity
acetylcholine binding
acetylcholine-gated cation channel activity
acetylcholine receptor activity
beta-amyloid binding
chloride channel regulator activity
protein homodimerization activity
toxic substance binding - Gene Ontology Cellular Component:
- acetylcholine-gated channel complex
cell junction
integral component of membrane
plasma membrane
postsynaptic membrane - Keywords:
- 3D-structure
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport