Names & Taxonomy
- Uniprot ID:
- P36405
- Entry Name:
- ARL3_HUMAN
- Status:
- reviewed
- Protein Names:
- ADP-ribosylation factor-like protein 3
- Gene Names:
- ARL3 ARFL3
- Gene Names Primary:
- ARL3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 182
- Sequence:
- MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWKNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQDGMNWVCKNVNAKKK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium. Note=Detected predominantly in the photoreceptor connecting cilium. Present on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules.
Function
- Function:
- Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit.
- Gene Ontology Go:
- centrosome
cytoplasmic microtubule
extracellular exosome
Golgi apparatus
Golgi membrane
midbody
nucleus
photoreceptor connecting cilium
primary cilium
spindle microtubule
GDP binding
GTP binding
GTPase activity
metal ion binding
microtubule binding
cilium morphogenesis
cytokinesis
intraciliary transport
kidney development
organelle organization
photoreceptor cell development
post-Golgi vesicle-mediated transport
small GTPase mediated signal transduction
smoothened signaling pathway - Gene Ontology Biological Process:
- cilium morphogenesis
cytokinesis
intraciliary transport
kidney development
organelle organization
photoreceptor cell development
post-Golgi vesicle-mediated transport
small GTPase mediated signal transduction
smoothened signaling pathway - Gene Ontology Molecular Function:
- GDP binding
GTPase activity
GTP binding
metal ion binding
microtubule binding - Gene Ontology Cellular Component:
- centrosome
cytoplasmic microtubule
extracellular exosome
Golgi apparatus
Golgi membrane
midbody
nucleus
photoreceptor connecting cilium
primary cilium
spindle microtubule - Keywords:
- Cell cycle
Cell division
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
GTP-binding
Golgi apparatus
Lipoprotein
Magnesium
Membrane
Metal-binding
Myristate
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Protein transport
Reference proteome
Transport - Interacts With:
- O43924; Q13432